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Coralysis

This is the development version of Coralysis; to use it, please install the devel version of Bioconductor.

Coralysis sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration


Bioconductor version: Development (3.22)

Coralysis is an R package featuring a multi-level integration algorithm for sensitive integration, reference-mapping, and cell-state identification in single-cell data. The multi-level integration algorithm is inspired by the process of assembling a puzzle - where one begins by grouping pieces based on low-to high-level features, such as color and shading, before looking into shape and patterns. This approach progressively blends the batch effects and separates cell types across multiple rounds of divisive clustering.

Author: António Sousa [cre, aut] ORCID iD ORCID: 0000-0003-4779-6459 , Johannes Smolander [ctb, aut] ORCID iD ORCID: 0000-0003-3872-9668 , Sini Junttila [aut] ORCID iD ORCID: 0000-0003-3754-5584 , Laura L Elo [aut] ORCID iD ORCID: 0000-0001-5648-4532

Maintainer: António Sousa <aggode at utu.fi>

Citation (from within R, enter citation("Coralysis")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("Coralysis")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("Coralysis")
Cell States HTML R Script
Get started HTML R Script
Integration HTML R Script
Reference-mapping HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews Annotation, BatchEffect, Classification, Clustering, DifferentialExpression, DimensionReduction, GeneExpression, Proteomics, RNASeq, SingleCell, Software, Transcriptomics
Version 0.99.6
In Bioconductor since BioC 3.22 (R-4.5)
License GPL-3
Depends R (>= 4.2.0)
Imports Matrix, aricode, LiblineaR, SparseM, ggplot2, umap, Rtsne, pheatmap, reshape2, dplyr, SingleCellExperiment, SummarizedExperiment, S4Vectors, methods, stats, utils, RANN, sparseMatrixStats, irlba, flexclust, scran, class, matrixStats, tidyr, cowplot, uwot, scatterpie, RColorBrewer, ggrastr, ggrepel, RSpectra, BiocParallel, withr
System Requirements
URL https://github.com/elolab/Coralysis https://elolab.github.io/Coralysis/
Bug Reports https://github.com/elolab/Coralysis/issues
See More
Suggests knitr, rmarkdown, bluster, ComplexHeatmap, circlize, scater, viridis, scRNAseq, SingleR, MouseGastrulationData, testthat (>= 3.0.0), BiocStyle, scrapper
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Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package Coralysis_0.99.6.tar.gz
Windows Binary (x86_64)
macOS Binary (x86_64) Coralysis_0.99.6.tgz
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/Coralysis
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/Coralysis
Bioc Package Browser https://code.bioconductor.org/browse/Coralysis/
Package Short Url https://bioconductor.org/packages/Coralysis/
Package Downloads Report Download Stats