Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
##
## Attaching package: 'MatrixGenerics'
## The following objects are masked from 'package:matrixStats':
##
## colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse,
## colCounts, colCummaxs, colCummins, colCumprods, colCumsums,
## colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs,
## colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
## colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds,
## colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads,
## colWeightedMeans, colWeightedMedians, colWeightedSds,
## colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet,
## rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods,
## rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps,
## rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins,
## rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks,
## rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars,
## rowWeightedMads, rowWeightedMeans, rowWeightedMedians,
## rowWeightedSds, rowWeightedVars
## Loading required package: GenomicRanges
## Loading required package: stats4
## Loading required package: BiocGenerics
## Loading required package: generics
##
## Attaching package: 'generics'
## The following objects are masked from 'package:base':
##
## as.difftime, as.factor, as.ordered, intersect, is.element, setdiff,
## setequal, union
##
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:stats':
##
## IQR, mad, sd, var, xtabs
## The following objects are masked from 'package:base':
##
## Filter, Find, Map, Position, Reduce, anyDuplicated, aperm, append,
## as.data.frame, basename, cbind, colnames, dirname, do.call,
## duplicated, eval, evalq, get, grep, grepl, is.unsorted, lapply,
## mapply, match, mget, order, paste, pmax, pmax.int, pmin, pmin.int,
## rank, rbind, rownames, sapply, saveRDS, table, tapply, unique,
## unsplit, which.max, which.min
## Loading required package: S4Vectors
##
## Attaching package: 'S4Vectors'
## The following object is masked from 'package:utils':
##
## findMatches
## The following objects are masked from 'package:base':
##
## I, expand.grid, unname
## Loading required package: IRanges
## Loading required package: GenomeInfoDb
## Loading required package: Biobase
## Welcome to Bioconductor
##
## Vignettes contain introductory material; view with
## 'browseVignettes()'. To cite Bioconductor, see
## 'citation("Biobase")', and for packages 'citation("pkgname")'.
##
## Attaching package: 'Biobase'
## The following object is masked from 'package:MatrixGenerics':
##
## rowMedians
## The following objects are masked from 'package:matrixStats':
##
## anyMissing, rowMedians
prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2025-05-28 16:45:08.807582 INFO::Creating output folder.
## 2025-05-28 16:45:08.813622 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2025-05-28 16:45:08.83591 INFO::Summarized Experiment created.
## 2025-05-28 16:45:08.836557 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2025-05-28 16:45:11.014807 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2025-05-28 16:45:11.016899 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2025-05-28 16:45:12.187337 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2025-05-28 16:45:12.826286 INFO::Writing function arguments to log file
## 2025-05-28 16:45:12.828661 INFO::Verifying options selected are valid
## 2025-05-28 16:45:12.848057 INFO::Determining format of input files
## 2025-05-28 16:45:12.848568 INFO::Input format is data samples as columns and metadata samples as rows
## 2025-05-28 16:45:12.854705 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2025-05-28 16:45:12.855295 INFO::Filter data based on min abundance and min prevalence
## 2025-05-28 16:45:12.855536 INFO::Total samples in data: 102
## 2025-05-28 16:45:12.855753 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2025-05-28 16:45:12.860061 INFO::Total filtered features: 0
## 2025-05-28 16:45:12.860442 INFO::Filtered feature names from abundance and prevalence filtering:
## 2025-05-28 16:45:12.866865 INFO::Total filtered features with variance filtering: 0
## 2025-05-28 16:45:12.867281 INFO::Filtered feature names from variance filtering:
## 2025-05-28 16:45:12.867548 INFO::Running selected normalization method: NONE
## 2025-05-28 16:45:12.867985 INFO::Applying z-score to standardize continuous metadata
## 2025-05-28 16:45:12.877702 INFO::Running selected transform method: NONE
## 2025-05-28 16:45:12.87823 INFO::Running selected analysis method: LM
## 2025-05-28 16:45:12.880704 INFO::Fitting model to feature number 1, F1
## 2025-05-28 16:45:12.884991 INFO::Fitting model to feature number 2, F2
## 2025-05-28 16:45:12.886345 INFO::Fitting model to feature number 3, F3
## 2025-05-28 16:45:12.887509 INFO::Fitting model to feature number 4, F4
## 2025-05-28 16:45:12.888684 INFO::Fitting model to feature number 5, F5
## 2025-05-28 16:45:12.889908 INFO::Fitting model to feature number 6, F6
## 2025-05-28 16:45:12.891085 INFO::Fitting model to feature number 7, F7
## 2025-05-28 16:45:12.892205 INFO::Fitting model to feature number 8, F8
## 2025-05-28 16:45:12.893321 INFO::Fitting model to feature number 9, F9
## 2025-05-28 16:45:12.894451 INFO::Fitting model to feature number 10, F10
## 2025-05-28 16:45:12.89556 INFO::Fitting model to feature number 11, F11
## 2025-05-28 16:45:12.896653 INFO::Fitting model to feature number 12, F12
## 2025-05-28 16:45:12.897751 INFO::Fitting model to feature number 13, F13
## 2025-05-28 16:45:12.898854 INFO::Fitting model to feature number 14, F14
## 2025-05-28 16:45:12.899973 INFO::Fitting model to feature number 15, F15
## 2025-05-28 16:45:12.901062 INFO::Fitting model to feature number 16, F16
## 2025-05-28 16:45:12.902156 INFO::Fitting model to feature number 17, F17
## 2025-05-28 16:45:12.903267 INFO::Fitting model to feature number 18, F18
## 2025-05-28 16:45:12.90435 INFO::Fitting model to feature number 19, F19
## 2025-05-28 16:45:12.905444 INFO::Fitting model to feature number 20, F20
## 2025-05-28 16:45:12.906538 INFO::Fitting model to feature number 21, F21
## 2025-05-28 16:45:12.907632 INFO::Fitting model to feature number 22, F22
## 2025-05-28 16:45:12.908698 INFO::Fitting model to feature number 23, F23
## 2025-05-28 16:45:12.909796 INFO::Fitting model to feature number 24, F24
## 2025-05-28 16:45:12.910864 INFO::Fitting model to feature number 25, F25
## 2025-05-28 16:45:12.911936 INFO::Fitting model to feature number 26, F26
## 2025-05-28 16:45:12.913093 INFO::Fitting model to feature number 27, F27
## 2025-05-28 16:45:12.914165 INFO::Fitting model to feature number 28, F28
## 2025-05-28 16:45:12.915265 INFO::Fitting model to feature number 29, F29
## 2025-05-28 16:45:12.916343 INFO::Fitting model to feature number 30, F30
## 2025-05-28 16:45:12.917425 INFO::Fitting model to feature number 31, F31
## 2025-05-28 16:45:12.918601 INFO::Fitting model to feature number 32, F32
## 2025-05-28 16:45:12.919688 INFO::Fitting model to feature number 33, F33
## 2025-05-28 16:45:12.92077 INFO::Fitting model to feature number 34, F34
## 2025-05-28 16:45:12.921857 INFO::Fitting model to feature number 35, F35
## 2025-05-28 16:45:12.922962 INFO::Fitting model to feature number 36, F36
## 2025-05-28 16:45:12.92406 INFO::Fitting model to feature number 37, F37
## 2025-05-28 16:45:12.925185 INFO::Fitting model to feature number 38, F38
## 2025-05-28 16:45:12.92628 INFO::Fitting model to feature number 39, F39
## 2025-05-28 16:45:12.927373 INFO::Fitting model to feature number 40, F40
## 2025-05-28 16:45:12.928455 INFO::Fitting model to feature number 41, F41
## 2025-05-28 16:45:12.929546 INFO::Fitting model to feature number 42, F43
## 2025-05-28 16:45:12.930658 INFO::Fitting model to feature number 43, F44
## 2025-05-28 16:45:12.931722 INFO::Fitting model to feature number 44, F45
## 2025-05-28 16:45:12.932787 INFO::Fitting model to feature number 45, F46
## 2025-05-28 16:45:12.933872 INFO::Fitting model to feature number 46, F47
## 2025-05-28 16:45:12.934956 INFO::Fitting model to feature number 47, F48
## 2025-05-28 16:45:12.936036 INFO::Fitting model to feature number 48, F49
## 2025-05-28 16:45:12.937124 INFO::Fitting model to feature number 49, F50
## 2025-05-28 16:45:12.938217 INFO::Fitting model to feature number 50, F51
## 2025-05-28 16:45:12.939339 INFO::Fitting model to feature number 51, F52
## 2025-05-28 16:45:12.940441 INFO::Fitting model to feature number 52, F53
## 2025-05-28 16:45:12.941516 INFO::Fitting model to feature number 53, F54
## 2025-05-28 16:45:12.942592 INFO::Fitting model to feature number 54, F55
## 2025-05-28 16:45:12.943661 INFO::Fitting model to feature number 55, F56
## 2025-05-28 16:45:12.944733 INFO::Fitting model to feature number 56, F57
## 2025-05-28 16:45:12.945805 INFO::Fitting model to feature number 57, F58
## 2025-05-28 16:45:12.946883 INFO::Fitting model to feature number 58, F59
## 2025-05-28 16:45:12.948031 INFO::Fitting model to feature number 59, F60
## 2025-05-28 16:45:12.949128 INFO::Fitting model to feature number 60, F63
## 2025-05-28 16:45:12.950232 INFO::Fitting model to feature number 61, F64
## 2025-05-28 16:45:12.951377 INFO::Fitting model to feature number 62, F65
## 2025-05-28 16:45:12.9525 INFO::Fitting model to feature number 63, F66
## 2025-05-28 16:45:12.953593 INFO::Fitting model to feature number 64, F67
## 2025-05-28 16:45:12.954678 INFO::Fitting model to feature number 65, F68
## 2025-05-28 16:45:12.955768 INFO::Fitting model to feature number 66, F69
## 2025-05-28 16:45:12.956854 INFO::Fitting model to feature number 67, F70
## 2025-05-28 16:45:12.957952 INFO::Fitting model to feature number 68, F71
## 2025-05-28 16:45:12.959045 INFO::Fitting model to feature number 69, F72
## 2025-05-28 16:45:12.960129 INFO::Fitting model to feature number 70, F73
## 2025-05-28 16:45:12.961233 INFO::Fitting model to feature number 71, F74
## 2025-05-28 16:45:12.962321 INFO::Fitting model to feature number 72, F76
## 2025-05-28 16:45:12.963415 INFO::Fitting model to feature number 73, F77
## 2025-05-28 16:45:12.964517 INFO::Fitting model to feature number 74, F78
## 2025-05-28 16:45:12.965604 INFO::Fitting model to feature number 75, F79
## 2025-05-28 16:45:12.966691 INFO::Fitting model to feature number 76, F80
## 2025-05-28 16:45:12.967784 INFO::Fitting model to feature number 77, F81
## 2025-05-28 16:45:12.968874 INFO::Fitting model to feature number 78, F82
## 2025-05-28 16:45:12.969958 INFO::Fitting model to feature number 79, F83
## 2025-05-28 16:45:12.971032 INFO::Fitting model to feature number 80, F84
## 2025-05-28 16:45:12.972109 INFO::Fitting model to feature number 81, F85
## 2025-05-28 16:45:12.973195 INFO::Fitting model to feature number 82, F86
## 2025-05-28 16:45:12.97441 INFO::Fitting model to feature number 83, F87
## 2025-05-28 16:45:12.9755 INFO::Fitting model to feature number 84, F88
## 2025-05-28 16:45:12.976615 INFO::Fitting model to feature number 85, F89
## 2025-05-28 16:45:12.977728 INFO::Fitting model to feature number 86, F90
## 2025-05-28 16:45:12.97887 INFO::Fitting model to feature number 87, F91
## 2025-05-28 16:45:12.979983 INFO::Fitting model to feature number 88, F92
## 2025-05-28 16:45:12.981066 INFO::Fitting model to feature number 89, F93
## 2025-05-28 16:45:12.982159 INFO::Fitting model to feature number 90, F94
## 2025-05-28 16:45:12.983251 INFO::Fitting model to feature number 91, F95
## 2025-05-28 16:45:12.984386 INFO::Fitting model to feature number 92, F96
## 2025-05-28 16:45:12.985517 INFO::Fitting model to feature number 93, F97
## 2025-05-28 16:45:12.986643 INFO::Fitting model to feature number 94, F98
## 2025-05-28 16:45:12.987811 INFO::Fitting model to feature number 95, F99
## 2025-05-28 16:45:12.988976 INFO::Fitting model to feature number 96, F100
## 2025-05-28 16:45:12.990154 INFO::Fitting model to feature number 97, F101
## 2025-05-28 16:45:12.991296 INFO::Fitting model to feature number 98, F102
## 2025-05-28 16:45:12.992485 INFO::Fitting model to feature number 99, F103
## 2025-05-28 16:45:12.993647 INFO::Fitting model to feature number 100, F104
## 2025-05-28 16:45:12.994738 INFO::Fitting model to feature number 101, F105
## 2025-05-28 16:45:12.995828 INFO::Fitting model to feature number 102, F106
## 2025-05-28 16:45:12.996914 INFO::Fitting model to feature number 103, F107
## 2025-05-28 16:45:12.998066 INFO::Fitting model to feature number 104, F108
## 2025-05-28 16:45:12.999176 INFO::Fitting model to feature number 105, F109
## 2025-05-28 16:45:13.000294 INFO::Fitting model to feature number 106, F110
## 2025-05-28 16:45:13.001399 INFO::Fitting model to feature number 107, F111
## 2025-05-28 16:45:13.00252 INFO::Fitting model to feature number 108, F112
## 2025-05-28 16:45:13.003609 INFO::Fitting model to feature number 109, F113
## 2025-05-28 16:45:13.004707 INFO::Fitting model to feature number 110, F114
## 2025-05-28 16:45:13.005792 INFO::Fitting model to feature number 111, F115
## 2025-05-28 16:45:13.006907 INFO::Fitting model to feature number 112, F117
## 2025-05-28 16:45:13.008007 INFO::Fitting model to feature number 113, F118
## 2025-05-28 16:45:13.009178 INFO::Fitting model to feature number 114, F119
## 2025-05-28 16:45:13.01029 INFO::Fitting model to feature number 115, F120
## 2025-05-28 16:45:13.011405 INFO::Fitting model to feature number 116, F121
## 2025-05-28 16:45:13.0125 INFO::Fitting model to feature number 117, F122
## 2025-05-28 16:45:13.013644 INFO::Fitting model to feature number 118, F123
## 2025-05-28 16:45:13.014764 INFO::Fitting model to feature number 119, F124
## 2025-05-28 16:45:13.015881 INFO::Fitting model to feature number 120, F125
## 2025-05-28 16:45:13.016991 INFO::Fitting model to feature number 121, F126
## 2025-05-28 16:45:13.018069 INFO::Fitting model to feature number 122, F127
## 2025-05-28 16:45:13.019144 INFO::Fitting model to feature number 123, F128
## 2025-05-28 16:45:13.020217 INFO::Fitting model to feature number 124, F129
## 2025-05-28 16:45:13.021285 INFO::Fitting model to feature number 125, F130
## 2025-05-28 16:45:13.022392 INFO::Fitting model to feature number 126, F131
## 2025-05-28 16:45:13.02347 INFO::Fitting model to feature number 127, F132
## 2025-05-28 16:45:13.024561 INFO::Fitting model to feature number 128, F133
## 2025-05-28 16:45:13.025633 INFO::Fitting model to feature number 129, F134
## 2025-05-28 16:45:13.026719 INFO::Fitting model to feature number 130, F135
## 2025-05-28 16:45:13.02779 INFO::Fitting model to feature number 131, F136
## 2025-05-28 16:45:13.028872 INFO::Fitting model to feature number 132, F137
## 2025-05-28 16:45:13.029945 INFO::Fitting model to feature number 133, F138
## 2025-05-28 16:45:13.03105 INFO::Fitting model to feature number 134, F139
## 2025-05-28 16:45:13.032125 INFO::Fitting model to feature number 135, F140
## 2025-05-28 16:45:13.033211 INFO::Fitting model to feature number 136, F141
## 2025-05-28 16:45:13.034285 INFO::Fitting model to feature number 137, F142
## 2025-05-28 16:45:13.035435 INFO::Fitting model to feature number 138, F143
## 2025-05-28 16:45:13.037066 INFO::Fitting model to feature number 139, F144
## 2025-05-28 16:45:13.038441 INFO::Fitting model to feature number 140, F145
## 2025-05-28 16:45:13.039659 INFO::Fitting model to feature number 141, F146
## 2025-05-28 16:45:13.040857 INFO::Fitting model to feature number 142, F147
## 2025-05-28 16:45:13.041987 INFO::Fitting model to feature number 143, F148
## 2025-05-28 16:45:13.043102 INFO::Fitting model to feature number 144, F149
## 2025-05-28 16:45:13.044218 INFO::Fitting model to feature number 145, F150
## 2025-05-28 16:45:13.04532 INFO::Fitting model to feature number 146, F152
## 2025-05-28 16:45:13.046405 INFO::Fitting model to feature number 147, F153
## 2025-05-28 16:45:13.047503 INFO::Fitting model to feature number 148, F154
## 2025-05-28 16:45:13.048605 INFO::Fitting model to feature number 149, F155
## 2025-05-28 16:45:13.049711 INFO::Fitting model to feature number 150, F156
## 2025-05-28 16:45:13.050814 INFO::Fitting model to feature number 151, F157
## 2025-05-28 16:45:13.051911 INFO::Fitting model to feature number 152, F158
## 2025-05-28 16:45:13.053033 INFO::Fitting model to feature number 153, F159
## 2025-05-28 16:45:13.054208 INFO::Fitting model to feature number 154, F160
## 2025-05-28 16:45:13.055319 INFO::Fitting model to feature number 155, F161
## 2025-05-28 16:45:13.056427 INFO::Fitting model to feature number 156, F162
## 2025-05-28 16:45:13.057537 INFO::Fitting model to feature number 157, F163
## 2025-05-28 16:45:13.058648 INFO::Fitting model to feature number 158, F164
## 2025-05-28 16:45:13.059734 INFO::Fitting model to feature number 159, F165
## 2025-05-28 16:45:13.060826 INFO::Fitting model to feature number 160, F166
## 2025-05-28 16:45:13.061925 INFO::Fitting model to feature number 161, F167
## 2025-05-28 16:45:13.063018 INFO::Fitting model to feature number 162, F168
## 2025-05-28 16:45:13.064118 INFO::Fitting model to feature number 163, F169
## 2025-05-28 16:45:13.065271 INFO::Fitting model to feature number 164, F170
## 2025-05-28 16:45:13.066355 INFO::Fitting model to feature number 165, F171
## 2025-05-28 16:45:13.067438 INFO::Fitting model to feature number 166, F172
## 2025-05-28 16:45:13.068543 INFO::Fitting model to feature number 167, F173
## 2025-05-28 16:45:13.069658 INFO::Fitting model to feature number 168, F174
## 2025-05-28 16:45:13.070769 INFO::Fitting model to feature number 169, F175
## 2025-05-28 16:45:13.071914 INFO::Fitting model to feature number 170, F176
## 2025-05-28 16:45:13.073049 INFO::Fitting model to feature number 171, F177
## 2025-05-28 16:45:13.074194 INFO::Fitting model to feature number 172, F178
## 2025-05-28 16:45:13.075338 INFO::Fitting model to feature number 173, F179
## 2025-05-28 16:45:13.076475 INFO::Fitting model to feature number 174, F180
## 2025-05-28 16:45:13.077647 INFO::Fitting model to feature number 175, F181
## 2025-05-28 16:45:13.078765 INFO::Fitting model to feature number 176, F182
## 2025-05-28 16:45:13.079885 INFO::Fitting model to feature number 177, F183
## 2025-05-28 16:45:13.080998 INFO::Fitting model to feature number 178, F184
## 2025-05-28 16:45:13.082115 INFO::Fitting model to feature number 179, F185
## 2025-05-28 16:45:13.083228 INFO::Fitting model to feature number 180, F186
## 2025-05-28 16:45:13.084385 INFO::Fitting model to feature number 181, F187
## 2025-05-28 16:45:13.08552 INFO::Fitting model to feature number 182, F188
## 2025-05-28 16:45:13.086614 INFO::Fitting model to feature number 183, F189
## 2025-05-28 16:45:13.087725 INFO::Fitting model to feature number 184, F190
## 2025-05-28 16:45:13.088835 INFO::Fitting model to feature number 185, F191
## 2025-05-28 16:45:13.089943 INFO::Fitting model to feature number 186, F192
## 2025-05-28 16:45:13.091052 INFO::Fitting model to feature number 187, F193
## 2025-05-28 16:45:13.092139 INFO::Fitting model to feature number 188, F194
## 2025-05-28 16:45:13.09324 INFO::Fitting model to feature number 189, F195
## 2025-05-28 16:45:13.094352 INFO::Fitting model to feature number 190, F196
## 2025-05-28 16:45:13.09545 INFO::Fitting model to feature number 191, F197
## 2025-05-28 16:45:13.096552 INFO::Fitting model to feature number 192, F198
## 2025-05-28 16:45:13.097733 INFO::Fitting model to feature number 193, F199
## 2025-05-28 16:45:13.098818 INFO::Fitting model to feature number 194, F200
## 2025-05-28 16:45:13.099892 INFO::Fitting model to feature number 195, F201
## 2025-05-28 16:45:13.100976 INFO::Fitting model to feature number 196, F202
## 2025-05-28 16:45:13.102069 INFO::Fitting model to feature number 197, F203
## 2025-05-28 16:45:13.103164 INFO::Fitting model to feature number 198, F204
## 2025-05-28 16:45:13.104249 INFO::Fitting model to feature number 199, F206
## 2025-05-28 16:45:13.105326 INFO::Fitting model to feature number 200, F207
## 2025-05-28 16:45:13.106396 INFO::Fitting model to feature number 201, F208
## 2025-05-28 16:45:13.107527 INFO::Fitting model to feature number 202, F209
## 2025-05-28 16:45:13.108602 INFO::Fitting model to feature number 203, F210
## 2025-05-28 16:45:13.109674 INFO::Fitting model to feature number 204, F211
## 2025-05-28 16:45:13.110769 INFO::Fitting model to feature number 205, F212
## 2025-05-28 16:45:13.111859 INFO::Fitting model to feature number 206, F213
## 2025-05-28 16:45:13.112946 INFO::Fitting model to feature number 207, F214
## 2025-05-28 16:45:13.114037 INFO::Fitting model to feature number 208, F215
## 2025-05-28 16:45:13.115139 INFO::Fitting model to feature number 209, F216
## 2025-05-28 16:45:13.116226 INFO::Fitting model to feature number 210, F217
## 2025-05-28 16:45:13.117319 INFO::Fitting model to feature number 211, F218
## 2025-05-28 16:45:13.118404 INFO::Fitting model to feature number 212, F219
## 2025-05-28 16:45:13.119481 INFO::Fitting model to feature number 213, F220
## 2025-05-28 16:45:13.120562 INFO::Fitting model to feature number 214, F221
## 2025-05-28 16:45:13.121654 INFO::Fitting model to feature number 215, F222
## 2025-05-28 16:45:13.122728 INFO::Fitting model to feature number 216, F223
## 2025-05-28 16:45:13.142796 INFO::Fitting model to feature number 217, F224
## 2025-05-28 16:45:13.144235 INFO::Fitting model to feature number 218, F225
## 2025-05-28 16:45:13.145397 INFO::Fitting model to feature number 219, F226
## 2025-05-28 16:45:13.14655 INFO::Fitting model to feature number 220, F227
## 2025-05-28 16:45:13.147702 INFO::Fitting model to feature number 221, F228
## 2025-05-28 16:45:13.148832 INFO::Fitting model to feature number 222, F229
## 2025-05-28 16:45:13.149947 INFO::Fitting model to feature number 223, F230
## 2025-05-28 16:45:13.151068 INFO::Fitting model to feature number 224, F231
## 2025-05-28 16:45:13.152171 INFO::Fitting model to feature number 225, F232
## 2025-05-28 16:45:13.153248 INFO::Fitting model to feature number 226, F233
## 2025-05-28 16:45:13.15434 INFO::Fitting model to feature number 227, F234
## 2025-05-28 16:45:13.155428 INFO::Fitting model to feature number 228, F235
## 2025-05-28 16:45:13.15652 INFO::Fitting model to feature number 229, F236
## 2025-05-28 16:45:13.157612 INFO::Fitting model to feature number 230, F237
## 2025-05-28 16:45:13.158727 INFO::Fitting model to feature number 231, F238
## 2025-05-28 16:45:13.159857 INFO::Fitting model to feature number 232, F239
## 2025-05-28 16:45:13.160987 INFO::Fitting model to feature number 233, F240
## 2025-05-28 16:45:13.162108 INFO::Fitting model to feature number 234, F241
## 2025-05-28 16:45:13.163236 INFO::Fitting model to feature number 235, F242
## 2025-05-28 16:45:13.164344 INFO::Fitting model to feature number 236, F243
## 2025-05-28 16:45:13.165436 INFO::Fitting model to feature number 237, F244
## 2025-05-28 16:45:13.166523 INFO::Fitting model to feature number 238, F245
## 2025-05-28 16:45:13.167605 INFO::Fitting model to feature number 239, F246
## 2025-05-28 16:45:13.168682 INFO::Fitting model to feature number 240, F247
## 2025-05-28 16:45:13.169774 INFO::Fitting model to feature number 241, F248
## 2025-05-28 16:45:13.170858 INFO::Fitting model to feature number 242, F249
## 2025-05-28 16:45:13.171964 INFO::Fitting model to feature number 243, F250
## 2025-05-28 16:45:13.17305 INFO::Fitting model to feature number 244, F252
## 2025-05-28 16:45:13.174134 INFO::Fitting model to feature number 245, F253
## 2025-05-28 16:45:13.175225 INFO::Fitting model to feature number 246, F254
## 2025-05-28 16:45:13.176373 INFO::Fitting model to feature number 247, F255
## 2025-05-28 16:45:13.177465 INFO::Fitting model to feature number 248, F256
## 2025-05-28 16:45:13.178538 INFO::Fitting model to feature number 249, F257
## 2025-05-28 16:45:13.179616 INFO::Fitting model to feature number 250, F259
## 2025-05-28 16:45:13.18074 INFO::Fitting model to feature number 251, F260
## 2025-05-28 16:45:13.181832 INFO::Fitting model to feature number 252, F261
## 2025-05-28 16:45:13.182932 INFO::Fitting model to feature number 253, F262
## 2025-05-28 16:45:13.184004 INFO::Fitting model to feature number 254, F263
## 2025-05-28 16:45:13.18509 INFO::Fitting model to feature number 255, F264
## 2025-05-28 16:45:13.186178 INFO::Fitting model to feature number 256, F265
## 2025-05-28 16:45:13.187291 INFO::Fitting model to feature number 257, F266
## 2025-05-28 16:45:13.188421 INFO::Fitting model to feature number 258, F267
## 2025-05-28 16:45:13.18955 INFO::Fitting model to feature number 259, F269
## 2025-05-28 16:45:13.190693 INFO::Fitting model to feature number 260, F270
## 2025-05-28 16:45:13.19184 INFO::Fitting model to feature number 261, F271
## 2025-05-28 16:45:13.192991 INFO::Fitting model to feature number 262, F272
## 2025-05-28 16:45:13.194135 INFO::Fitting model to feature number 263, F273
## 2025-05-28 16:45:13.195219 INFO::Fitting model to feature number 264, F274
## 2025-05-28 16:45:13.196286 INFO::Fitting model to feature number 265, F276
## 2025-05-28 16:45:13.197362 INFO::Fitting model to feature number 266, F277
## 2025-05-28 16:45:13.198443 INFO::Fitting model to feature number 267, F278
## 2025-05-28 16:45:13.199518 INFO::Fitting model to feature number 268, F279
## 2025-05-28 16:45:13.2006 INFO::Fitting model to feature number 269, F280
## 2025-05-28 16:45:13.201671 INFO::Fitting model to feature number 270, F281
## 2025-05-28 16:45:13.202729 INFO::Fitting model to feature number 271, F282
## 2025-05-28 16:45:13.20378 INFO::Fitting model to feature number 272, F283
## 2025-05-28 16:45:13.204849 INFO::Fitting model to feature number 273, F284
## 2025-05-28 16:45:13.205926 INFO::Fitting model to feature number 274, F285
## 2025-05-28 16:45:13.20699 INFO::Fitting model to feature number 275, F286
## 2025-05-28 16:45:13.208081 INFO::Fitting model to feature number 276, F287
## 2025-05-28 16:45:13.209147 INFO::Fitting model to feature number 277, F288
## 2025-05-28 16:45:13.210207 INFO::Fitting model to feature number 278, F289
## 2025-05-28 16:45:13.21127 INFO::Fitting model to feature number 279, F290
## 2025-05-28 16:45:13.212333 INFO::Fitting model to feature number 280, F292
## 2025-05-28 16:45:13.213378 INFO::Fitting model to feature number 281, F293
## 2025-05-28 16:45:13.21444 INFO::Fitting model to feature number 282, F294
## 2025-05-28 16:45:13.215506 INFO::Fitting model to feature number 283, F295
## 2025-05-28 16:45:13.216558 INFO::Fitting model to feature number 284, F296
## 2025-05-28 16:45:13.217622 INFO::Fitting model to feature number 285, F297
## 2025-05-28 16:45:13.218691 INFO::Fitting model to feature number 286, F298
## 2025-05-28 16:45:13.219756 INFO::Fitting model to feature number 287, F299
## 2025-05-28 16:45:13.220819 INFO::Fitting model to feature number 288, F300
## 2025-05-28 16:45:13.221878 INFO::Fitting model to feature number 289, F301
## 2025-05-28 16:45:13.222949 INFO::Fitting model to feature number 290, F302
## 2025-05-28 16:45:13.224014 INFO::Fitting model to feature number 291, F303
## 2025-05-28 16:45:13.225099 INFO::Fitting model to feature number 292, F304
## 2025-05-28 16:45:13.226187 INFO::Fitting model to feature number 293, F305
## 2025-05-28 16:45:13.227284 INFO::Fitting model to feature number 294, F306
## 2025-05-28 16:45:13.228371 INFO::Fitting model to feature number 295, F307
## 2025-05-28 16:45:13.229476 INFO::Fitting model to feature number 296, F308
## 2025-05-28 16:45:13.230582 INFO::Fitting model to feature number 297, F309
## 2025-05-28 16:45:13.231684 INFO::Fitting model to feature number 298, F310
## 2025-05-28 16:45:13.232799 INFO::Fitting model to feature number 299, F311
## 2025-05-28 16:45:13.233879 INFO::Fitting model to feature number 300, F312
## 2025-05-28 16:45:13.234991 INFO::Fitting model to feature number 301, F313
## 2025-05-28 16:45:13.236145 INFO::Fitting model to feature number 302, F315
## 2025-05-28 16:45:13.23722 INFO::Fitting model to feature number 303, F316
## 2025-05-28 16:45:13.23828 INFO::Fitting model to feature number 304, F317
## 2025-05-28 16:45:13.239346 INFO::Fitting model to feature number 305, F318
## 2025-05-28 16:45:13.240394 INFO::Fitting model to feature number 306, F319
## 2025-05-28 16:45:13.241439 INFO::Fitting model to feature number 307, F320
## 2025-05-28 16:45:13.242482 INFO::Fitting model to feature number 308, F321
## 2025-05-28 16:45:13.243532 INFO::Fitting model to feature number 309, F322
## 2025-05-28 16:45:13.244587 INFO::Fitting model to feature number 310, F323
## 2025-05-28 16:45:13.245655 INFO::Fitting model to feature number 311, F324
## 2025-05-28 16:45:13.246712 INFO::Fitting model to feature number 312, F325
## 2025-05-28 16:45:13.247773 INFO::Fitting model to feature number 313, F326
## 2025-05-28 16:45:13.248837 INFO::Fitting model to feature number 314, F327
## 2025-05-28 16:45:13.249886 INFO::Fitting model to feature number 315, F328
## 2025-05-28 16:45:13.250957 INFO::Fitting model to feature number 316, F329
## 2025-05-28 16:45:13.25201 INFO::Fitting model to feature number 317, F330
## 2025-05-28 16:45:13.253055 INFO::Fitting model to feature number 318, F331
## 2025-05-28 16:45:13.2541 INFO::Fitting model to feature number 319, F332
## 2025-05-28 16:45:13.255151 INFO::Fitting model to feature number 320, F333
## 2025-05-28 16:45:13.25621 INFO::Fitting model to feature number 321, F334
## 2025-05-28 16:45:13.257295 INFO::Fitting model to feature number 322, F335
## 2025-05-28 16:45:13.258384 INFO::Fitting model to feature number 323, F336
## 2025-05-28 16:45:13.25949 INFO::Fitting model to feature number 324, F337
## 2025-05-28 16:45:13.260616 INFO::Fitting model to feature number 325, F338
## 2025-05-28 16:45:13.261752 INFO::Fitting model to feature number 326, F339
## 2025-05-28 16:45:13.262959 INFO::Fitting model to feature number 327, F340
## 2025-05-28 16:45:13.264079 INFO::Fitting model to feature number 328, F342
## 2025-05-28 16:45:13.26518 INFO::Fitting model to feature number 329, F343
## 2025-05-28 16:45:13.266266 INFO::Fitting model to feature number 330, F344
## 2025-05-28 16:45:13.267361 INFO::Fitting model to feature number 331, F345
## 2025-05-28 16:45:13.26849 INFO::Fitting model to feature number 332, F346
## 2025-05-28 16:45:13.269577 INFO::Fitting model to feature number 333, F347
## 2025-05-28 16:45:13.270666 INFO::Fitting model to feature number 334, F348
## 2025-05-28 16:45:13.271793 INFO::Fitting model to feature number 335, F350
## 2025-05-28 16:45:13.272884 INFO::Fitting model to feature number 336, F351
## 2025-05-28 16:45:13.273983 INFO::Fitting model to feature number 337, F352
## 2025-05-28 16:45:13.2751 INFO::Fitting model to feature number 338, F353
## 2025-05-28 16:45:13.276212 INFO::Fitting model to feature number 339, F355
## 2025-05-28 16:45:13.277314 INFO::Fitting model to feature number 340, F356
## 2025-05-28 16:45:13.278404 INFO::Fitting model to feature number 341, F357
## 2025-05-28 16:45:13.279505 INFO::Fitting model to feature number 342, F358
## 2025-05-28 16:45:13.280608 INFO::Fitting model to feature number 343, F359
## 2025-05-28 16:45:13.2817 INFO::Fitting model to feature number 344, F360
## 2025-05-28 16:45:13.282798 INFO::Fitting model to feature number 345, F361
## 2025-05-28 16:45:13.283915 INFO::Fitting model to feature number 346, F362
## 2025-05-28 16:45:13.285017 INFO::Fitting model to feature number 347, F363
## 2025-05-28 16:45:13.286105 INFO::Fitting model to feature number 348, F364
## 2025-05-28 16:45:13.287246 INFO::Fitting model to feature number 349, F365
## 2025-05-28 16:45:13.288465 INFO::Fitting model to feature number 350, F366
## 2025-05-28 16:45:13.289584 INFO::Fitting model to feature number 351, F367
## 2025-05-28 16:45:13.290677 INFO::Fitting model to feature number 352, F368
## 2025-05-28 16:45:13.291796 INFO::Fitting model to feature number 353, F369
## 2025-05-28 16:45:13.292918 INFO::Fitting model to feature number 354, F370
## 2025-05-28 16:45:13.294042 INFO::Fitting model to feature number 355, F371
## 2025-05-28 16:45:13.295169 INFO::Fitting model to feature number 356, F372
## 2025-05-28 16:45:13.29631 INFO::Fitting model to feature number 357, F373
## 2025-05-28 16:45:13.297413 INFO::Fitting model to feature number 358, F374
## 2025-05-28 16:45:13.298512 INFO::Fitting model to feature number 359, F375
## 2025-05-28 16:45:13.299606 INFO::Fitting model to feature number 360, F376
## 2025-05-28 16:45:13.300683 INFO::Fitting model to feature number 361, F377
## 2025-05-28 16:45:13.301777 INFO::Fitting model to feature number 362, F378
## 2025-05-28 16:45:13.302866 INFO::Fitting model to feature number 363, F379
## 2025-05-28 16:45:13.303967 INFO::Fitting model to feature number 364, F380
## 2025-05-28 16:45:13.305092 INFO::Fitting model to feature number 365, F381
## 2025-05-28 16:45:13.306249 INFO::Fitting model to feature number 366, F382
## 2025-05-28 16:45:13.30736 INFO::Fitting model to feature number 367, F383
## 2025-05-28 16:45:13.308507 INFO::Fitting model to feature number 368, F384
## 2025-05-28 16:45:13.309681 INFO::Fitting model to feature number 369, F386
## 2025-05-28 16:45:13.310801 INFO::Fitting model to feature number 370, F387
## 2025-05-28 16:45:13.311898 INFO::Fitting model to feature number 371, F388
## 2025-05-28 16:45:13.31299 INFO::Fitting model to feature number 372, F389
## 2025-05-28 16:45:13.314095 INFO::Fitting model to feature number 373, F390
## 2025-05-28 16:45:13.315191 INFO::Fitting model to feature number 374, F391
## 2025-05-28 16:45:13.316276 INFO::Fitting model to feature number 375, F392
## 2025-05-28 16:45:13.317383 INFO::Fitting model to feature number 376, F393
## 2025-05-28 16:45:13.318485 INFO::Fitting model to feature number 377, F394
## 2025-05-28 16:45:13.319594 INFO::Fitting model to feature number 378, F395
## 2025-05-28 16:45:13.320696 INFO::Fitting model to feature number 379, F396
## 2025-05-28 16:45:13.321818 INFO::Fitting model to feature number 380, F397
## 2025-05-28 16:45:13.322956 INFO::Fitting model to feature number 381, F398
## 2025-05-28 16:45:13.324104 INFO::Fitting model to feature number 382, F399
## 2025-05-28 16:45:13.325252 INFO::Fitting model to feature number 383, F400
## 2025-05-28 16:45:13.326386 INFO::Fitting model to feature number 384, F401
## 2025-05-28 16:45:13.327511 INFO::Fitting model to feature number 385, F402
## 2025-05-28 16:45:13.328616 INFO::Fitting model to feature number 386, F403
## 2025-05-28 16:45:13.329735 INFO::Fitting model to feature number 387, F404
## 2025-05-28 16:45:13.330854 INFO::Fitting model to feature number 388, F406
## 2025-05-28 16:45:13.331968 INFO::Fitting model to feature number 389, F407
## 2025-05-28 16:45:13.333075 INFO::Fitting model to feature number 390, F408
## 2025-05-28 16:45:13.33418 INFO::Fitting model to feature number 391, F409
## 2025-05-28 16:45:13.335271 INFO::Fitting model to feature number 392, F410
## 2025-05-28 16:45:13.336373 INFO::Fitting model to feature number 393, F411
## 2025-05-28 16:45:13.337478 INFO::Fitting model to feature number 394, F412
## 2025-05-28 16:45:13.338612 INFO::Fitting model to feature number 395, F413
## 2025-05-28 16:45:13.339755 INFO::Fitting model to feature number 396, F414
## 2025-05-28 16:45:13.340873 INFO::Fitting model to feature number 397, F415
## 2025-05-28 16:45:13.342 INFO::Fitting model to feature number 398, F416
## 2025-05-28 16:45:13.343124 INFO::Fitting model to feature number 399, F417
## 2025-05-28 16:45:13.344261 INFO::Fitting model to feature number 400, F418
## 2025-05-28 16:45:13.345378 INFO::Fitting model to feature number 401, F419
## 2025-05-28 16:45:13.346473 INFO::Fitting model to feature number 402, F420
## 2025-05-28 16:45:13.347803 INFO::Fitting model to feature number 403, F421
## 2025-05-28 16:45:13.349096 INFO::Fitting model to feature number 404, F422
## 2025-05-28 16:45:13.350315 INFO::Fitting model to feature number 405, F423
## 2025-05-28 16:45:13.351514 INFO::Fitting model to feature number 406, F425
## 2025-05-28 16:45:13.352674 INFO::Fitting model to feature number 407, F426
## 2025-05-28 16:45:13.353815 INFO::Fitting model to feature number 408, F428
## 2025-05-28 16:45:13.354947 INFO::Fitting model to feature number 409, F429
## 2025-05-28 16:45:13.356089 INFO::Fitting model to feature number 410, F430
## 2025-05-28 16:45:13.357247 INFO::Fitting model to feature number 411, F431
## 2025-05-28 16:45:13.358467 INFO::Fitting model to feature number 412, F432
## 2025-05-28 16:45:13.359665 INFO::Fitting model to feature number 413, F433
## 2025-05-28 16:45:13.360835 INFO::Fitting model to feature number 414, F434
## 2025-05-28 16:45:13.362007 INFO::Fitting model to feature number 415, F435
## 2025-05-28 16:45:13.363195 INFO::Fitting model to feature number 416, F436
## 2025-05-28 16:45:13.364403 INFO::Fitting model to feature number 417, F437
## 2025-05-28 16:45:13.365553 INFO::Fitting model to feature number 418, F438
## 2025-05-28 16:45:13.36666 INFO::Fitting model to feature number 419, F439
## 2025-05-28 16:45:13.367771 INFO::Fitting model to feature number 420, F440
## 2025-05-28 16:45:13.368893 INFO::Fitting model to feature number 421, F441
## 2025-05-28 16:45:13.370006 INFO::Fitting model to feature number 422, F442
## 2025-05-28 16:45:13.371126 INFO::Fitting model to feature number 423, F443
## 2025-05-28 16:45:13.372247 INFO::Fitting model to feature number 424, F444
## 2025-05-28 16:45:13.373361 INFO::Fitting model to feature number 425, F445
## 2025-05-28 16:45:13.374465 INFO::Fitting model to feature number 426, F446
## 2025-05-28 16:45:13.375567 INFO::Fitting model to feature number 427, F447
## 2025-05-28 16:45:13.376662 INFO::Fitting model to feature number 428, F448
## 2025-05-28 16:45:13.377774 INFO::Fitting model to feature number 429, F449
## 2025-05-28 16:45:13.378883 INFO::Fitting model to feature number 430, F450
## 2025-05-28 16:45:13.379974 INFO::Fitting model to feature number 431, F451
## 2025-05-28 16:45:13.381057 INFO::Fitting model to feature number 432, F452
## 2025-05-28 16:45:13.382153 INFO::Fitting model to feature number 433, F454
## 2025-05-28 16:45:13.38329 INFO::Fitting model to feature number 434, F455
## 2025-05-28 16:45:13.384416 INFO::Fitting model to feature number 435, F456
## 2025-05-28 16:45:13.385534 INFO::Fitting model to feature number 436, F457
## 2025-05-28 16:45:13.386823 INFO::Fitting model to feature number 437, F458
## 2025-05-28 16:45:13.388058 INFO::Fitting model to feature number 438, F459
## 2025-05-28 16:45:13.389225 INFO::Fitting model to feature number 439, F461
## 2025-05-28 16:45:13.390385 INFO::Fitting model to feature number 440, F462
## 2025-05-28 16:45:13.391481 INFO::Fitting model to feature number 441, F463
## 2025-05-28 16:45:13.392615 INFO::Fitting model to feature number 442, F464
## 2025-05-28 16:45:13.393748 INFO::Fitting model to feature number 443, F465
## 2025-05-28 16:45:13.394867 INFO::Fitting model to feature number 444, F466
## 2025-05-28 16:45:13.395992 INFO::Fitting model to feature number 445, F467
## 2025-05-28 16:45:13.397131 INFO::Fitting model to feature number 446, F468
## 2025-05-28 16:45:13.398259 INFO::Fitting model to feature number 447, F469
## 2025-05-28 16:45:13.399385 INFO::Fitting model to feature number 448, F470
## 2025-05-28 16:45:13.400545 INFO::Fitting model to feature number 449, F471
## 2025-05-28 16:45:13.401726 INFO::Fitting model to feature number 450, F474
## 2025-05-28 16:45:13.402861 INFO::Fitting model to feature number 451, F475
## 2025-05-28 16:45:13.403996 INFO::Fitting model to feature number 452, F476
## 2025-05-28 16:45:13.405135 INFO::Fitting model to feature number 453, F477
## 2025-05-28 16:45:13.406274 INFO::Fitting model to feature number 454, F478
## 2025-05-28 16:45:13.407387 INFO::Fitting model to feature number 455, F479
## 2025-05-28 16:45:13.408507 INFO::Fitting model to feature number 456, F480
## 2025-05-28 16:45:13.409612 INFO::Fitting model to feature number 457, F481
## 2025-05-28 16:45:13.410719 INFO::Fitting model to feature number 458, F482
## 2025-05-28 16:45:13.411821 INFO::Fitting model to feature number 459, F483
## 2025-05-28 16:45:13.41293 INFO::Fitting model to feature number 460, F484
## 2025-05-28 16:45:13.414035 INFO::Fitting model to feature number 461, F485
## 2025-05-28 16:45:13.415156 INFO::Fitting model to feature number 462, F486
## 2025-05-28 16:45:13.416261 INFO::Fitting model to feature number 463, F487
## 2025-05-28 16:45:13.417379 INFO::Fitting model to feature number 464, F488
## 2025-05-28 16:45:13.418483 INFO::Fitting model to feature number 465, F489
## 2025-05-28 16:45:13.419617 INFO::Fitting model to feature number 466, F490
## 2025-05-28 16:45:13.420722 INFO::Fitting model to feature number 467, F491
## 2025-05-28 16:45:13.421833 INFO::Fitting model to feature number 468, F492
## 2025-05-28 16:45:13.422962 INFO::Fitting model to feature number 469, F493
## 2025-05-28 16:45:13.424054 INFO::Fitting model to feature number 470, F494
## 2025-05-28 16:45:13.425159 INFO::Fitting model to feature number 471, F495
## 2025-05-28 16:45:13.426254 INFO::Fitting model to feature number 472, F496
## 2025-05-28 16:45:13.427348 INFO::Fitting model to feature number 473, F497
## 2025-05-28 16:45:13.428458 INFO::Fitting model to feature number 474, F498
## 2025-05-28 16:45:13.429583 INFO::Fitting model to feature number 475, F499
## 2025-05-28 16:45:13.430693 INFO::Fitting model to feature number 476, F500
## 2025-05-28 16:45:13.431785 INFO::Fitting model to feature number 477, F501
## 2025-05-28 16:45:13.432907 INFO::Fitting model to feature number 478, F502
## 2025-05-28 16:45:13.434014 INFO::Fitting model to feature number 479, F503
## 2025-05-28 16:45:13.435123 INFO::Fitting model to feature number 480, F504
## 2025-05-28 16:45:13.436244 INFO::Fitting model to feature number 481, F505
## 2025-05-28 16:45:13.437348 INFO::Fitting model to feature number 482, F506
## 2025-05-28 16:45:13.438448 INFO::Fitting model to feature number 483, F507
## 2025-05-28 16:45:13.439547 INFO::Fitting model to feature number 484, F508
## 2025-05-28 16:45:13.44065 INFO::Fitting model to feature number 485, F509
## 2025-05-28 16:45:13.441769 INFO::Fitting model to feature number 486, F510
## 2025-05-28 16:45:13.442884 INFO::Fitting model to feature number 487, F511
## 2025-05-28 16:45:13.443996 INFO::Fitting model to feature number 488, F512
## 2025-05-28 16:45:13.445097 INFO::Fitting model to feature number 489, F513
## 2025-05-28 16:45:13.446203 INFO::Fitting model to feature number 490, F514
## 2025-05-28 16:45:13.447322 INFO::Fitting model to feature number 491, F515
## 2025-05-28 16:45:13.448436 INFO::Fitting model to feature number 492, F516
## 2025-05-28 16:45:13.449809 INFO::Fitting model to feature number 493, F517
## 2025-05-28 16:45:13.450947 INFO::Fitting model to feature number 494, F518
## 2025-05-28 16:45:13.452081 INFO::Fitting model to feature number 495, F519
## 2025-05-28 16:45:13.453221 INFO::Fitting model to feature number 496, F520
## 2025-05-28 16:45:13.454387 INFO::Fitting model to feature number 497, F521
## 2025-05-28 16:45:13.455533 INFO::Fitting model to feature number 498, F522
## 2025-05-28 16:45:13.456684 INFO::Fitting model to feature number 499, F523
## 2025-05-28 16:45:13.457833 INFO::Fitting model to feature number 500, F524
## 2025-05-28 16:45:13.458955 INFO::Fitting model to feature number 501, F525
## 2025-05-28 16:45:13.460084 INFO::Fitting model to feature number 502, F526
## 2025-05-28 16:45:13.461169 INFO::Fitting model to feature number 503, F527
## 2025-05-28 16:45:13.462235 INFO::Fitting model to feature number 504, F528
## 2025-05-28 16:45:13.463301 INFO::Fitting model to feature number 505, F529
## 2025-05-28 16:45:13.464414 INFO::Fitting model to feature number 506, F530
## 2025-05-28 16:45:13.465514 INFO::Fitting model to feature number 507, F531
## 2025-05-28 16:45:13.466631 INFO::Fitting model to feature number 508, F532
## 2025-05-28 16:45:13.467722 INFO::Fitting model to feature number 509, F533
## 2025-05-28 16:45:13.468833 INFO::Fitting model to feature number 510, F534
## 2025-05-28 16:45:13.469939 INFO::Fitting model to feature number 511, F535
## 2025-05-28 16:45:13.471076 INFO::Fitting model to feature number 512, F536
## 2025-05-28 16:45:13.472193 INFO::Fitting model to feature number 513, F537
## 2025-05-28 16:45:13.473292 INFO::Fitting model to feature number 514, F539
## 2025-05-28 16:45:13.474414 INFO::Fitting model to feature number 515, F540
## 2025-05-28 16:45:13.475519 INFO::Fitting model to feature number 516, F541
## 2025-05-28 16:45:13.476636 INFO::Fitting model to feature number 517, F543
## 2025-05-28 16:45:13.477736 INFO::Fitting model to feature number 518, F544
## 2025-05-28 16:45:13.478906 INFO::Fitting model to feature number 519, F545
## 2025-05-28 16:45:13.479994 INFO::Fitting model to feature number 520, F546
## 2025-05-28 16:45:13.481115 INFO::Fitting model to feature number 521, F547
## 2025-05-28 16:45:13.482203 INFO::Fitting model to feature number 522, F548
## 2025-05-28 16:45:13.483295 INFO::Fitting model to feature number 523, F549
## 2025-05-28 16:45:13.484378 INFO::Fitting model to feature number 524, F550
## 2025-05-28 16:45:13.485465 INFO::Fitting model to feature number 525, F551
## 2025-05-28 16:45:13.486557 INFO::Fitting model to feature number 526, F552
## 2025-05-28 16:45:13.487645 INFO::Fitting model to feature number 527, F553
## 2025-05-28 16:45:13.488713 INFO::Fitting model to feature number 528, F554
## 2025-05-28 16:45:13.490244 INFO::Fitting model to feature number 529, F555
## 2025-05-28 16:45:13.491422 INFO::Fitting model to feature number 530, F556
## 2025-05-28 16:45:13.49257 INFO::Fitting model to feature number 531, F557
## 2025-05-28 16:45:13.511419 INFO::Fitting model to feature number 532, F558
## 2025-05-28 16:45:13.513344 INFO::Fitting model to feature number 533, F559
## 2025-05-28 16:45:13.514733 INFO::Fitting model to feature number 534, F560
## 2025-05-28 16:45:13.51597 INFO::Fitting model to feature number 535, F561
## 2025-05-28 16:45:13.517115 INFO::Fitting model to feature number 536, F562
## 2025-05-28 16:45:13.518237 INFO::Fitting model to feature number 537, F563
## 2025-05-28 16:45:13.519376 INFO::Fitting model to feature number 538, F564
## 2025-05-28 16:45:13.520684 INFO::Fitting model to feature number 539, F566
## 2025-05-28 16:45:13.521852 INFO::Fitting model to feature number 540, F567
## 2025-05-28 16:45:13.522995 INFO::Fitting model to feature number 541, F568
## 2025-05-28 16:45:13.524102 INFO::Fitting model to feature number 542, F569
## 2025-05-28 16:45:13.525211 INFO::Fitting model to feature number 543, F570
## 2025-05-28 16:45:13.526424 INFO::Fitting model to feature number 544, F571
## 2025-05-28 16:45:13.52769 INFO::Fitting model to feature number 545, F572
## 2025-05-28 16:45:13.528829 INFO::Fitting model to feature number 546, F573
## 2025-05-28 16:45:13.530082 INFO::Fitting model to feature number 547, F574
## 2025-05-28 16:45:13.531302 INFO::Fitting model to feature number 548, F575
## 2025-05-28 16:45:13.532461 INFO::Fitting model to feature number 549, F576
## 2025-05-28 16:45:13.533563 INFO::Fitting model to feature number 550, F577
## 2025-05-28 16:45:13.534709 INFO::Fitting model to feature number 551, F578
## 2025-05-28 16:45:13.535866 INFO::Fitting model to feature number 552, F579
## 2025-05-28 16:45:13.537007 INFO::Fitting model to feature number 553, F580
## 2025-05-28 16:45:13.538126 INFO::Fitting model to feature number 554, F581
## 2025-05-28 16:45:13.53939 INFO::Fitting model to feature number 555, F582
## 2025-05-28 16:45:13.540626 INFO::Fitting model to feature number 556, F583
## 2025-05-28 16:45:13.541853 INFO::Fitting model to feature number 557, F584
## 2025-05-28 16:45:13.543036 INFO::Fitting model to feature number 558, F585
## 2025-05-28 16:45:13.544278 INFO::Fitting model to feature number 559, F586
## 2025-05-28 16:45:13.545469 INFO::Fitting model to feature number 560, F587
## 2025-05-28 16:45:13.546629 INFO::Fitting model to feature number 561, F588
## 2025-05-28 16:45:13.547732 INFO::Fitting model to feature number 562, F589
## 2025-05-28 16:45:13.548815 INFO::Fitting model to feature number 563, F590
## 2025-05-28 16:45:13.549901 INFO::Fitting model to feature number 564, F591
## 2025-05-28 16:45:13.551002 INFO::Fitting model to feature number 565, F592
## 2025-05-28 16:45:13.552096 INFO::Fitting model to feature number 566, F593
## 2025-05-28 16:45:13.553181 INFO::Fitting model to feature number 567, F594
## 2025-05-28 16:45:13.554248 INFO::Fitting model to feature number 568, F595
## 2025-05-28 16:45:13.55535 INFO::Fitting model to feature number 569, F596
## 2025-05-28 16:45:13.556423 INFO::Fitting model to feature number 570, F597
## 2025-05-28 16:45:13.557519 INFO::Fitting model to feature number 571, F598
## 2025-05-28 16:45:13.558605 INFO::Fitting model to feature number 572, F599
## 2025-05-28 16:45:13.559687 INFO::Fitting model to feature number 573, F600
## 2025-05-28 16:45:13.5608 INFO::Fitting model to feature number 574, F601
## 2025-05-28 16:45:13.561881 INFO::Fitting model to feature number 575, F602
## 2025-05-28 16:45:13.562996 INFO::Fitting model to feature number 576, F603
## 2025-05-28 16:45:13.564065 INFO::Fitting model to feature number 577, F605
## 2025-05-28 16:45:13.565144 INFO::Fitting model to feature number 578, F606
## 2025-05-28 16:45:13.566211 INFO::Fitting model to feature number 579, F607
## 2025-05-28 16:45:13.567258 INFO::Fitting model to feature number 580, F608
## 2025-05-28 16:45:13.568344 INFO::Fitting model to feature number 581, F609
## 2025-05-28 16:45:13.569394 INFO::Fitting model to feature number 582, F610
## 2025-05-28 16:45:13.57045 INFO::Fitting model to feature number 583, F611
## 2025-05-28 16:45:13.571531 INFO::Fitting model to feature number 584, F612
## 2025-05-28 16:45:13.5726 INFO::Fitting model to feature number 585, F613
## 2025-05-28 16:45:13.57368 INFO::Fitting model to feature number 586, F614
## 2025-05-28 16:45:13.574731 INFO::Fitting model to feature number 587, F615
## 2025-05-28 16:45:13.575802 INFO::Fitting model to feature number 588, F616
## 2025-05-28 16:45:13.576861 INFO::Fitting model to feature number 589, F617
## 2025-05-28 16:45:13.577931 INFO::Fitting model to feature number 590, F618
## 2025-05-28 16:45:13.579027 INFO::Fitting model to feature number 591, F619
## 2025-05-28 16:45:13.580083 INFO::Fitting model to feature number 592, F620
## 2025-05-28 16:45:13.581138 INFO::Fitting model to feature number 593, F621
## 2025-05-28 16:45:13.582194 INFO::Fitting model to feature number 594, F622
## 2025-05-28 16:45:13.583262 INFO::Fitting model to feature number 595, F623
## 2025-05-28 16:45:13.584331 INFO::Fitting model to feature number 596, F624
## 2025-05-28 16:45:13.585431 INFO::Fitting model to feature number 597, F625
## 2025-05-28 16:45:13.586493 INFO::Fitting model to feature number 598, F626
## 2025-05-28 16:45:13.587545 INFO::Fitting model to feature number 599, F627
## 2025-05-28 16:45:13.588625 INFO::Fitting model to feature number 600, F628
## 2025-05-28 16:45:13.589906 INFO::Fitting model to feature number 601, F629
## 2025-05-28 16:45:13.591167 INFO::Fitting model to feature number 602, F630
## 2025-05-28 16:45:13.59233 INFO::Fitting model to feature number 603, F631
## 2025-05-28 16:45:13.593668 INFO::Fitting model to feature number 604, F632
## 2025-05-28 16:45:13.594864 INFO::Fitting model to feature number 605, F633
## 2025-05-28 16:45:13.596011 INFO::Fitting model to feature number 606, F634
## 2025-05-28 16:45:13.597157 INFO::Fitting model to feature number 607, F635
## 2025-05-28 16:45:13.598275 INFO::Fitting model to feature number 608, F636
## 2025-05-28 16:45:13.599378 INFO::Fitting model to feature number 609, F637
## 2025-05-28 16:45:13.600512 INFO::Fitting model to feature number 610, F638
## 2025-05-28 16:45:13.601648 INFO::Fitting model to feature number 611, F639
## 2025-05-28 16:45:13.602916 INFO::Fitting model to feature number 612, F640
## 2025-05-28 16:45:13.604113 INFO::Fitting model to feature number 613, F641
## 2025-05-28 16:45:13.605263 INFO::Fitting model to feature number 614, F642
## 2025-05-28 16:45:13.606378 INFO::Fitting model to feature number 615, F643
## 2025-05-28 16:45:13.607485 INFO::Fitting model to feature number 616, F644
## 2025-05-28 16:45:13.608588 INFO::Fitting model to feature number 617, F645
## 2025-05-28 16:45:13.609704 INFO::Fitting model to feature number 618, F646
## 2025-05-28 16:45:13.610791 INFO::Fitting model to feature number 619, F647
## 2025-05-28 16:45:13.611912 INFO::Fitting model to feature number 620, F648
## 2025-05-28 16:45:13.612997 INFO::Fitting model to feature number 621, F649
## 2025-05-28 16:45:13.614092 INFO::Fitting model to feature number 622, F650
## 2025-05-28 16:45:13.615179 INFO::Fitting model to feature number 623, F651
## 2025-05-28 16:45:13.616275 INFO::Fitting model to feature number 624, F652
## 2025-05-28 16:45:13.617515 INFO::Fitting model to feature number 625, F653
## 2025-05-28 16:45:13.618602 INFO::Fitting model to feature number 626, F654
## 2025-05-28 16:45:13.619691 INFO::Fitting model to feature number 627, F655
## 2025-05-28 16:45:13.620799 INFO::Fitting model to feature number 628, F656
## 2025-05-28 16:45:13.621864 INFO::Fitting model to feature number 629, F657
## 2025-05-28 16:45:13.62297 INFO::Fitting model to feature number 630, F658
## 2025-05-28 16:45:13.62404 INFO::Fitting model to feature number 631, F659
## 2025-05-28 16:45:13.625106 INFO::Fitting model to feature number 632, F660
## 2025-05-28 16:45:13.626164 INFO::Fitting model to feature number 633, F661
## 2025-05-28 16:45:13.627948 INFO::Fitting model to feature number 634, F662
## 2025-05-28 16:45:13.629106 INFO::Fitting model to feature number 635, F663
## 2025-05-28 16:45:13.630233 INFO::Fitting model to feature number 636, F664
## 2025-05-28 16:45:13.631326 INFO::Fitting model to feature number 637, F665
## 2025-05-28 16:45:13.632418 INFO::Fitting model to feature number 638, F666
## 2025-05-28 16:45:13.633494 INFO::Fitting model to feature number 639, F667
## 2025-05-28 16:45:13.63456 INFO::Fitting model to feature number 640, F668
## 2025-05-28 16:45:13.635641 INFO::Fitting model to feature number 641, F669
## 2025-05-28 16:45:13.636756 INFO::Fitting model to feature number 642, F670
## 2025-05-28 16:45:13.637903 INFO::Fitting model to feature number 643, F671
## 2025-05-28 16:45:13.639031 INFO::Fitting model to feature number 644, F672
## 2025-05-28 16:45:13.640143 INFO::Fitting model to feature number 645, F673
## 2025-05-28 16:45:13.641259 INFO::Fitting model to feature number 646, F674
## 2025-05-28 16:45:13.642427 INFO::Fitting model to feature number 647, F675
## 2025-05-28 16:45:13.643602 INFO::Fitting model to feature number 648, F676
## 2025-05-28 16:45:13.644768 INFO::Fitting model to feature number 649, F677
## 2025-05-28 16:45:13.645916 INFO::Fitting model to feature number 650, F678
## 2025-05-28 16:45:13.647021 INFO::Fitting model to feature number 651, F679
## 2025-05-28 16:45:13.648297 INFO::Fitting model to feature number 652, F680
## 2025-05-28 16:45:13.649581 INFO::Fitting model to feature number 653, F681
## 2025-05-28 16:45:13.650822 INFO::Fitting model to feature number 654, F682
## 2025-05-28 16:45:13.652086 INFO::Fitting model to feature number 655, F683
## 2025-05-28 16:45:13.653289 INFO::Fitting model to feature number 656, F684
## 2025-05-28 16:45:13.654444 INFO::Fitting model to feature number 657, F685
## 2025-05-28 16:45:13.655586 INFO::Fitting model to feature number 658, F686
## 2025-05-28 16:45:13.656737 INFO::Fitting model to feature number 659, F687
## 2025-05-28 16:45:13.657876 INFO::Fitting model to feature number 660, F688
## 2025-05-28 16:45:13.660094 INFO::Fitting model to feature number 661, F689
## 2025-05-28 16:45:13.661399 INFO::Fitting model to feature number 662, F690
## 2025-05-28 16:45:13.663231 INFO::Fitting model to feature number 663, F691
## 2025-05-28 16:45:13.664446 INFO::Fitting model to feature number 664, F692
## 2025-05-28 16:45:13.665559 INFO::Fitting model to feature number 665, F693
## 2025-05-28 16:45:13.666947 INFO::Fitting model to feature number 666, F694
## 2025-05-28 16:45:13.669247 INFO::Fitting model to feature number 667, F695
## 2025-05-28 16:45:13.670456 INFO::Fitting model to feature number 668, F696
## 2025-05-28 16:45:13.671625 INFO::Fitting model to feature number 669, F697
## 2025-05-28 16:45:13.672797 INFO::Fitting model to feature number 670, F698
## 2025-05-28 16:45:13.673967 INFO::Fitting model to feature number 671, F699
## 2025-05-28 16:45:13.675115 INFO::Fitting model to feature number 672, F700
## 2025-05-28 16:45:13.676251 INFO::Fitting model to feature number 673, F701
## 2025-05-28 16:45:13.677413 INFO::Fitting model to feature number 674, F702
## 2025-05-28 16:45:13.678597 INFO::Fitting model to feature number 675, F704
## 2025-05-28 16:45:13.679713 INFO::Fitting model to feature number 676, F705
## 2025-05-28 16:45:13.680865 INFO::Fitting model to feature number 677, F706
## 2025-05-28 16:45:13.681991 INFO::Fitting model to feature number 678, F707
## 2025-05-28 16:45:13.68312 INFO::Fitting model to feature number 679, F708
## 2025-05-28 16:45:13.685135 INFO::Fitting model to feature number 680, F709
## 2025-05-28 16:45:13.686442 INFO::Fitting model to feature number 681, F710
## 2025-05-28 16:45:13.688036 INFO::Fitting model to feature number 682, F711
## 2025-05-28 16:45:13.689654 INFO::Fitting model to feature number 683, F712
## 2025-05-28 16:45:13.691098 INFO::Fitting model to feature number 684, F713
## 2025-05-28 16:45:13.692442 INFO::Fitting model to feature number 685, F714
## 2025-05-28 16:45:13.693666 INFO::Fitting model to feature number 686, F715
## 2025-05-28 16:45:13.69487 INFO::Fitting model to feature number 687, F716
## 2025-05-28 16:45:13.696081 INFO::Fitting model to feature number 688, F717
## 2025-05-28 16:45:13.697252 INFO::Fitting model to feature number 689, F718
## 2025-05-28 16:45:13.698442 INFO::Fitting model to feature number 690, F719
## 2025-05-28 16:45:13.699603 INFO::Fitting model to feature number 691, F720
## 2025-05-28 16:45:13.700749 INFO::Fitting model to feature number 692, F721
## 2025-05-28 16:45:13.701854 INFO::Fitting model to feature number 693, F722
## 2025-05-28 16:45:13.702942 INFO::Fitting model to feature number 694, F723
## 2025-05-28 16:45:13.704036 INFO::Fitting model to feature number 695, F724
## 2025-05-28 16:45:13.705131 INFO::Fitting model to feature number 696, F725
## 2025-05-28 16:45:13.706243 INFO::Fitting model to feature number 697, F726
## 2025-05-28 16:45:13.707367 INFO::Fitting model to feature number 698, F727
## 2025-05-28 16:45:13.708473 INFO::Fitting model to feature number 699, F728
## 2025-05-28 16:45:13.709557 INFO::Fitting model to feature number 700, F729
## 2025-05-28 16:45:13.710642 INFO::Fitting model to feature number 701, F730
## 2025-05-28 16:45:13.711747 INFO::Fitting model to feature number 702, F731
## 2025-05-28 16:45:13.71282 INFO::Fitting model to feature number 703, F732
## 2025-05-28 16:45:13.713907 INFO::Fitting model to feature number 704, F733
## 2025-05-28 16:45:13.715 INFO::Fitting model to feature number 705, F734
## 2025-05-28 16:45:13.716111 INFO::Fitting model to feature number 706, F735
## 2025-05-28 16:45:13.717201 INFO::Fitting model to feature number 707, F736
## 2025-05-28 16:45:13.718315 INFO::Fitting model to feature number 708, F737
## 2025-05-28 16:45:13.719428 INFO::Fitting model to feature number 709, F739
## 2025-05-28 16:45:13.720503 INFO::Fitting model to feature number 710, F740
## 2025-05-28 16:45:13.721583 INFO::Fitting model to feature number 711, F741
## 2025-05-28 16:45:13.722673 INFO::Fitting model to feature number 712, F742
## 2025-05-28 16:45:13.723751 INFO::Fitting model to feature number 713, F743
## 2025-05-28 16:45:13.724841 INFO::Fitting model to feature number 714, F744
## 2025-05-28 16:45:13.725927 INFO::Fitting model to feature number 715, F745
## 2025-05-28 16:45:13.727005 INFO::Fitting model to feature number 716, F746
## 2025-05-28 16:45:13.728089 INFO::Fitting model to feature number 717, F747
## 2025-05-28 16:45:13.729177 INFO::Fitting model to feature number 718, F748
## 2025-05-28 16:45:13.730284 INFO::Fitting model to feature number 719, F749
## 2025-05-28 16:45:13.731396 INFO::Fitting model to feature number 720, F750
## 2025-05-28 16:45:13.732493 INFO::Fitting model to feature number 721, F751
## 2025-05-28 16:45:13.733585 INFO::Fitting model to feature number 722, F752
## 2025-05-28 16:45:13.734696 INFO::Fitting model to feature number 723, F753
## 2025-05-28 16:45:13.735808 INFO::Fitting model to feature number 724, F754
## 2025-05-28 16:45:13.736913 INFO::Fitting model to feature number 725, F755
## 2025-05-28 16:45:13.737994 INFO::Fitting model to feature number 726, F756
## 2025-05-28 16:45:13.739079 INFO::Fitting model to feature number 727, F757
## 2025-05-28 16:45:13.740157 INFO::Fitting model to feature number 728, F758
## 2025-05-28 16:45:13.741252 INFO::Fitting model to feature number 729, F759
## 2025-05-28 16:45:13.742345 INFO::Fitting model to feature number 730, F760
## 2025-05-28 16:45:13.743422 INFO::Fitting model to feature number 731, F761
## 2025-05-28 16:45:13.744532 INFO::Fitting model to feature number 732, F762
## 2025-05-28 16:45:13.745627 INFO::Fitting model to feature number 733, F763
## 2025-05-28 16:45:13.746712 INFO::Fitting model to feature number 734, F764
## 2025-05-28 16:45:13.747807 INFO::Fitting model to feature number 735, F765
## 2025-05-28 16:45:13.748932 INFO::Fitting model to feature number 736, F766
## 2025-05-28 16:45:13.750025 INFO::Fitting model to feature number 737, F767
## 2025-05-28 16:45:13.751103 INFO::Fitting model to feature number 738, F768
## 2025-05-28 16:45:13.752217 INFO::Fitting model to feature number 739, F769
## 2025-05-28 16:45:13.753406 INFO::Fitting model to feature number 740, F770
## 2025-05-28 16:45:13.754491 INFO::Fitting model to feature number 741, F771
## 2025-05-28 16:45:13.7556 INFO::Fitting model to feature number 742, F772
## 2025-05-28 16:45:13.756697 INFO::Fitting model to feature number 743, F773
## 2025-05-28 16:45:13.757792 INFO::Fitting model to feature number 744, F774
## 2025-05-28 16:45:13.758883 INFO::Fitting model to feature number 745, F775
## 2025-05-28 16:45:13.759956 INFO::Fitting model to feature number 746, F776
## 2025-05-28 16:45:13.761038 INFO::Fitting model to feature number 747, F777
## 2025-05-28 16:45:13.762102 INFO::Fitting model to feature number 748, F778
## 2025-05-28 16:45:13.763207 INFO::Fitting model to feature number 749, F779
## 2025-05-28 16:45:13.764301 INFO::Fitting model to feature number 750, F780
## 2025-05-28 16:45:13.765381 INFO::Fitting model to feature number 751, F781
## 2025-05-28 16:45:13.766464 INFO::Fitting model to feature number 752, F782
## 2025-05-28 16:45:13.767561 INFO::Fitting model to feature number 753, F783
## 2025-05-28 16:45:13.768663 INFO::Fitting model to feature number 754, F784
## 2025-05-28 16:45:13.769791 INFO::Fitting model to feature number 755, F785
## 2025-05-28 16:45:13.77088 INFO::Fitting model to feature number 756, F786
## 2025-05-28 16:45:13.771972 INFO::Fitting model to feature number 757, F787
## 2025-05-28 16:45:13.773093 INFO::Fitting model to feature number 758, F788
## 2025-05-28 16:45:13.774208 INFO::Fitting model to feature number 759, F789
## 2025-05-28 16:45:13.775289 INFO::Fitting model to feature number 760, F790
## 2025-05-28 16:45:13.77638 INFO::Fitting model to feature number 761, F791
## 2025-05-28 16:45:13.777466 INFO::Fitting model to feature number 762, F792
## 2025-05-28 16:45:13.778563 INFO::Fitting model to feature number 763, F793
## 2025-05-28 16:45:13.779672 INFO::Fitting model to feature number 764, F794
## 2025-05-28 16:45:13.780768 INFO::Fitting model to feature number 765, F795
## 2025-05-28 16:45:13.781851 INFO::Fitting model to feature number 766, F796
## 2025-05-28 16:45:13.782918 INFO::Fitting model to feature number 767, F797
## 2025-05-28 16:45:13.783998 INFO::Fitting model to feature number 768, F798
## 2025-05-28 16:45:13.785066 INFO::Fitting model to feature number 769, F799
## 2025-05-28 16:45:13.786149 INFO::Fitting model to feature number 770, F800
## 2025-05-28 16:45:13.787236 INFO::Fitting model to feature number 771, F801
## 2025-05-28 16:45:13.788329 INFO::Fitting model to feature number 772, F802
## 2025-05-28 16:45:13.789439 INFO::Fitting model to feature number 773, F803
## 2025-05-28 16:45:13.790551 INFO::Fitting model to feature number 774, F804
## 2025-05-28 16:45:13.791641 INFO::Fitting model to feature number 775, F805
## 2025-05-28 16:45:13.792719 INFO::Fitting model to feature number 776, F806
## 2025-05-28 16:45:13.793837 INFO::Fitting model to feature number 777, F808
## 2025-05-28 16:45:13.794939 INFO::Fitting model to feature number 778, F809
## 2025-05-28 16:45:13.796043 INFO::Fitting model to feature number 779, F810
## 2025-05-28 16:45:13.797161 INFO::Fitting model to feature number 780, F811
## 2025-05-28 16:45:13.798293 INFO::Fitting model to feature number 781, F812
## 2025-05-28 16:45:13.799431 INFO::Fitting model to feature number 782, F813
## 2025-05-28 16:45:13.800547 INFO::Fitting model to feature number 783, F814
## 2025-05-28 16:45:13.801632 INFO::Fitting model to feature number 784, F815
## 2025-05-28 16:45:13.802722 INFO::Fitting model to feature number 785, F816
## 2025-05-28 16:45:13.803846 INFO::Fitting model to feature number 786, F817
## 2025-05-28 16:45:13.804965 INFO::Fitting model to feature number 787, F818
## 2025-05-28 16:45:13.80608 INFO::Fitting model to feature number 788, F819
## 2025-05-28 16:45:13.80718 INFO::Fitting model to feature number 789, F820
## 2025-05-28 16:45:13.808299 INFO::Fitting model to feature number 790, F821
## 2025-05-28 16:45:13.809411 INFO::Fitting model to feature number 791, F822
## 2025-05-28 16:45:13.810535 INFO::Fitting model to feature number 792, F823
## 2025-05-28 16:45:13.811656 INFO::Fitting model to feature number 793, F824
## 2025-05-28 16:45:13.812826 INFO::Fitting model to feature number 794, F825
## 2025-05-28 16:45:13.813948 INFO::Fitting model to feature number 795, F826
## 2025-05-28 16:45:13.815085 INFO::Fitting model to feature number 796, F827
## 2025-05-28 16:45:13.816228 INFO::Fitting model to feature number 797, F828
## 2025-05-28 16:45:13.817343 INFO::Fitting model to feature number 798, F829
## 2025-05-28 16:45:13.818432 INFO::Fitting model to feature number 799, F830
## 2025-05-28 16:45:13.819533 INFO::Fitting model to feature number 800, F831
## 2025-05-28 16:45:13.820616 INFO::Fitting model to feature number 801, F832
## 2025-05-28 16:45:13.821692 INFO::Fitting model to feature number 802, F833
## 2025-05-28 16:45:13.82278 INFO::Fitting model to feature number 803, F834
## 2025-05-28 16:45:13.823875 INFO::Fitting model to feature number 804, F835
## 2025-05-28 16:45:13.824987 INFO::Fitting model to feature number 805, F836
## 2025-05-28 16:45:13.826076 INFO::Fitting model to feature number 806, F837
## 2025-05-28 16:45:13.827153 INFO::Fitting model to feature number 807, F838
## 2025-05-28 16:45:13.828246 INFO::Fitting model to feature number 808, F839
## 2025-05-28 16:45:13.829331 INFO::Fitting model to feature number 809, F840
## 2025-05-28 16:45:13.830439 INFO::Fitting model to feature number 810, F841
## 2025-05-28 16:45:13.831515 INFO::Fitting model to feature number 811, F842
## 2025-05-28 16:45:13.832601 INFO::Fitting model to feature number 812, F843
## 2025-05-28 16:45:13.833714 INFO::Fitting model to feature number 813, F844
## 2025-05-28 16:45:13.834819 INFO::Fitting model to feature number 814, F845
## 2025-05-28 16:45:13.835919 INFO::Fitting model to feature number 815, F846
## 2025-05-28 16:45:13.837003 INFO::Fitting model to feature number 816, F847
## 2025-05-28 16:45:13.838089 INFO::Fitting model to feature number 817, F848
## 2025-05-28 16:45:13.839188 INFO::Fitting model to feature number 818, F849
## 2025-05-28 16:45:13.840287 INFO::Fitting model to feature number 819, F850
## 2025-05-28 16:45:13.841395 INFO::Fitting model to feature number 820, F851
## 2025-05-28 16:45:13.842495 INFO::Fitting model to feature number 821, F852
## 2025-05-28 16:45:13.843599 INFO::Fitting model to feature number 822, F853
## 2025-05-28 16:45:13.844709 INFO::Fitting model to feature number 823, F854
## 2025-05-28 16:45:13.845779 INFO::Fitting model to feature number 824, F855
## 2025-05-28 16:45:13.846899 INFO::Fitting model to feature number 825, F856
## 2025-05-28 16:45:13.848383 INFO::Fitting model to feature number 826, F857
## 2025-05-28 16:45:13.849652 INFO::Fitting model to feature number 827, F858
## 2025-05-28 16:45:13.850844 INFO::Fitting model to feature number 828, F859
## 2025-05-28 16:45:13.852 INFO::Fitting model to feature number 829, F860
## 2025-05-28 16:45:13.85316 INFO::Fitting model to feature number 830, F861
## 2025-05-28 16:45:13.854269 INFO::Fitting model to feature number 831, F862
## 2025-05-28 16:45:13.855411 INFO::Fitting model to feature number 832, F863
## 2025-05-28 16:45:13.856546 INFO::Fitting model to feature number 833, F864
## 2025-05-28 16:45:13.857723 INFO::Fitting model to feature number 834, F865
## 2025-05-28 16:45:13.858819 INFO::Fitting model to feature number 835, F866
## 2025-05-28 16:45:13.859914 INFO::Fitting model to feature number 836, F867
## 2025-05-28 16:45:13.861019 INFO::Fitting model to feature number 837, F868
## 2025-05-28 16:45:13.862143 INFO::Fitting model to feature number 838, F869
## 2025-05-28 16:45:13.863263 INFO::Fitting model to feature number 839, F870
## 2025-05-28 16:45:13.86435 INFO::Fitting model to feature number 840, F871
## 2025-05-28 16:45:13.865444 INFO::Fitting model to feature number 841, F872
## 2025-05-28 16:45:13.866545 INFO::Fitting model to feature number 842, F873
## 2025-05-28 16:45:13.867628 INFO::Fitting model to feature number 843, F874
## 2025-05-28 16:45:13.868739 INFO::Fitting model to feature number 844, F875
## 2025-05-28 16:45:13.869848 INFO::Fitting model to feature number 845, F876
## 2025-05-28 16:45:13.870971 INFO::Fitting model to feature number 846, F877
## 2025-05-28 16:45:13.887249 INFO::Fitting model to feature number 847, F878
## 2025-05-28 16:45:13.888746 INFO::Fitting model to feature number 848, F879
## 2025-05-28 16:45:13.890015 INFO::Fitting model to feature number 849, F880
## 2025-05-28 16:45:13.891178 INFO::Fitting model to feature number 850, F881
## 2025-05-28 16:45:13.892337 INFO::Fitting model to feature number 851, F882
## 2025-05-28 16:45:13.893449 INFO::Fitting model to feature number 852, F883
## 2025-05-28 16:45:13.894568 INFO::Fitting model to feature number 853, F884
## 2025-05-28 16:45:13.89568 INFO::Fitting model to feature number 854, F885
## 2025-05-28 16:45:13.896802 INFO::Fitting model to feature number 855, F886
## 2025-05-28 16:45:13.89793 INFO::Fitting model to feature number 856, F887
## 2025-05-28 16:45:13.899034 INFO::Fitting model to feature number 857, F888
## 2025-05-28 16:45:13.900149 INFO::Fitting model to feature number 858, F889
## 2025-05-28 16:45:13.901246 INFO::Fitting model to feature number 859, F890
## 2025-05-28 16:45:13.902356 INFO::Fitting model to feature number 860, F891
## 2025-05-28 16:45:13.903464 INFO::Fitting model to feature number 861, F892
## 2025-05-28 16:45:13.904583 INFO::Fitting model to feature number 862, F893
## 2025-05-28 16:45:13.905689 INFO::Fitting model to feature number 863, F894
## 2025-05-28 16:45:13.906768 INFO::Fitting model to feature number 864, F895
## 2025-05-28 16:45:13.907853 INFO::Fitting model to feature number 865, F896
## 2025-05-28 16:45:13.908947 INFO::Fitting model to feature number 866, F897
## 2025-05-28 16:45:13.910075 INFO::Fitting model to feature number 867, F898
## 2025-05-28 16:45:13.911214 INFO::Fitting model to feature number 868, F899
## 2025-05-28 16:45:13.912354 INFO::Fitting model to feature number 869, F900
## 2025-05-28 16:45:13.969515 INFO::Counting total values for each feature
## 2025-05-28 16:45:14.013788 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2025-05-28 16:45:14.059492 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2025-05-28 16:45:14.106568 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2025-05-28 16:45:14.153193 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2025-05-28 16:45:14.17673 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2025-05-28 16:45:14.196456 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2025-05-28 16:45:14.20598 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2025-05-28 16:45:14.21029 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2025-05-28 16:45:14.218813 INFO::Plotting associations from most to least significant, grouped by metadata
## 2025-05-28 16:45:14.219355 INFO::Plotting data for metadata number 1, diagnosis
## 2025-05-28 16:45:14.236226 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2025-05-28 16:45:14.345858 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2025-05-28 16:45:14.413212 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2025-05-28 16:45:14.48467 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2025-05-28 16:45:14.543831 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2025-05-28 16:45:14.602634 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2025-05-28 16:45:14.661972 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2025-05-28 16:45:14.723839 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2025-05-28 16:45:14.788128 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2025-05-28 16:45:14.845884 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2025-05-28 16:45:14.904848 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2025-05-28 16:45:14.963681 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2025-05-28 16:45:15.02874 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2025-05-28 16:45:15.088685 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2025-05-28 16:45:15.146009 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2025-05-28 16:45:15.20403 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2025-05-28 16:45:15.262187 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2025-05-28 16:45:15.326317 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2025-05-28 16:45:15.382973 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2025-05-28 16:45:15.443749 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2025-05-28 16:45:15.504134 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2025-05-28 16:45:15.562448 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2025-05-28 16:45:15.657381 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2025-05-28 16:45:15.714498 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2025-05-28 16:45:15.772792 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2025-05-28 16:45:15.832773 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2025-05-28 16:45:15.891509 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2025-05-28 16:45:15.957328 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2025-05-28 16:45:16.015383 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2025-05-28 16:45:16.071072 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2025-05-28 16:45:16.12729 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2025-05-28 16:45:16.183121 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2025-05-28 16:45:16.250412 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2025-05-28 16:45:16.318553 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2025-05-28 16:45:16.374592 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2025-05-28 16:45:16.430248 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2025-05-28 16:45:16.486082 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2025-05-28 16:45:16.548816 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2025-05-28 16:45:16.604832 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2025-05-28 16:45:16.661013 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2025-05-28 16:45:16.716817 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2025-05-28 16:45:16.774453 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2025-05-28 16:45:16.837376 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2025-05-28 16:45:16.892305 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2025-05-28 16:45:16.948721 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2025-05-28 16:45:17.004907 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2025-05-28 16:45:17.060729 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2025-05-28 16:45:17.122784 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2025-05-28 16:45:17.178288 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2025-05-28 16:45:17.234158 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2025-05-28 16:45:17.290624 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2025-05-28 16:45:17.34611 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2025-05-28 16:45:17.410956 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2025-05-28 16:45:17.467445 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2025-05-28 16:45:17.523768 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2025-05-28 16:45:17.580689 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2025-05-28 16:45:17.642292 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2025-05-28 16:45:17.697365 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2025-05-28 16:45:17.751652 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2025-05-28 16:45:17.807339 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2025-05-28 16:45:17.862737 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2025-05-28 16:45:17.926461 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2025-05-28 16:45:17.981646 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2025-05-28 16:45:18.037209 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2025-05-28 16:45:18.092579 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2025-05-28 16:45:18.149886 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2025-05-28 16:45:18.215087 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2025-05-28 16:45:18.267885 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2025-05-28 16:45:18.32243 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2025-05-28 16:45:18.378133 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2025-05-28 16:45:18.433229 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2025-05-28 16:45:18.494984 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2025-05-28 16:45:18.549878 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2025-05-28 16:45:18.606373 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2025-05-28 16:45:18.660891 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2025-05-28 16:45:18.717847 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2025-05-28 16:45:18.783202 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2025-05-28 16:45:18.839559 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2025-05-28 16:45:18.895053 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2025-05-28 16:45:18.953064 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2025-05-28 16:45:19.015565 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2025-05-28 16:45:19.071401 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2025-05-28 16:45:19.127139 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2025-05-28 16:45:19.183664 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2025-05-28 16:45:19.23967 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2025-05-28 16:45:19.303261 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2025-05-28 16:45:19.358768 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2025-05-28 16:45:19.413746 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2025-05-28 16:45:19.470133 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2025-05-28 16:45:19.525594 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2025-05-28 16:45:19.588256 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2025-05-28 16:45:19.643883 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2025-05-28 16:45:19.701035 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2025-05-28 16:45:19.758959 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2025-05-28 16:45:19.818263 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2025-05-28 16:45:19.882223 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2025-05-28 16:45:19.937121 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2025-05-28 16:45:19.993865 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2025-05-28 16:45:20.051057 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2025-05-28 16:45:20.109185 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2025-05-28 16:45:20.173355 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2025-05-28 16:45:20.22969 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2025-05-28 16:45:20.287224 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2025-05-28 16:45:20.344641 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2025-05-28 16:45:20.408913 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2025-05-28 16:45:20.464878 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2025-05-28 16:45:20.521864 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2025-05-28 16:45:20.583945 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2025-05-28 16:45:20.643133 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2025-05-28 16:45:20.712294 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2025-05-28 16:45:20.772908 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2025-05-28 16:45:20.831812 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2025-05-28 16:45:20.887983 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2025-05-28 16:45:20.947446 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2025-05-28 16:45:21.015289 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2025-05-28 16:45:21.072421 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2025-05-28 16:45:21.129672 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2025-05-28 16:45:21.189077 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2025-05-28 16:45:21.256444 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2025-05-28 16:45:21.315691 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2025-05-28 16:45:21.37514 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2025-05-28 16:45:21.433595 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2025-05-28 16:45:21.492287 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2025-05-28 16:45:21.601891 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2025-05-28 16:45:21.6625 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2025-05-28 16:45:21.719865 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2025-05-28 16:45:21.785923 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2025-05-28 16:45:21.849602 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2025-05-28 16:45:21.920061 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2025-05-28 16:45:21.977623 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2025-05-28 16:45:22.036728 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2025-05-28 16:45:22.097359 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2025-05-28 16:45:22.157656 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2025-05-28 16:45:22.224774 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2025-05-28 16:45:22.284128 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2025-05-28 16:45:22.343365 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2025-05-28 16:45:22.401476 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2025-05-28 16:45:22.458145 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2025-05-28 16:45:22.52564 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2025-05-28 16:45:22.582696 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2025-05-28 16:45:22.641273 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2025-05-28 16:45:22.699876 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2025-05-28 16:45:22.757787 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2025-05-28 16:45:22.825667 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2025-05-28 16:45:22.88463 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2025-05-28 16:45:22.943968 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2025-05-28 16:45:23.00981 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2025-05-28 16:45:23.074816 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2025-05-28 16:45:23.136466 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2025-05-28 16:45:23.194254 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2025-05-28 16:45:23.256696 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2025-05-28 16:45:23.315088 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2025-05-28 16:45:23.38216 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2025-05-28 16:45:23.445403 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2025-05-28 16:45:23.503694 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2025-05-28 16:45:23.559791 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2025-05-28 16:45:23.615654 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2025-05-28 16:45:23.679154 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2025-05-28 16:45:23.735808 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2025-05-28 16:45:23.79195 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2025-05-28 16:45:23.848341 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2025-05-28 16:45:23.904886 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2025-05-28 16:45:23.97246 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2025-05-28 16:45:24.029623 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2025-05-28 16:45:24.085306 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2025-05-28 16:45:24.141355 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2025-05-28 16:45:24.196645 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2025-05-28 16:45:24.261367 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2025-05-28 16:45:24.316208 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2025-05-28 16:45:24.373026 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2025-05-28 16:45:24.429921 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2025-05-28 16:45:24.485671 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2025-05-28 16:45:24.552693 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2025-05-28 16:45:24.611752 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2025-05-28 16:45:24.672608 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2025-05-28 16:45:24.729661 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2025-05-28 16:45:24.796214 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2025-05-28 16:45:24.856062 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2025-05-28 16:45:24.913787 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2025-05-28 16:45:24.973443 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2025-05-28 16:45:25.031955 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2025-05-28 16:45:25.099156 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2025-05-28 16:45:25.156648 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2025-05-28 16:45:25.214262 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2025-05-28 16:45:25.270686 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2025-05-28 16:45:25.328162 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2025-05-28 16:45:25.395565 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2025-05-28 16:45:25.452338 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2025-05-28 16:45:25.511205 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2025-05-28 16:45:25.568614 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2025-05-28 16:45:25.626245 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2025-05-28 16:45:25.694704 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2025-05-28 16:45:25.755274 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2025-05-28 16:45:25.812475 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2025-05-28 16:45:25.869341 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2025-05-28 16:45:25.933674 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2025-05-28 16:45:25.993374 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2025-05-28 16:45:26.050785 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2025-05-28 16:45:26.108241 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2025-05-28 16:45:26.165018 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2025-05-28 16:45:26.230686 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2025-05-28 16:45:26.28775 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2025-05-28 16:45:26.344445 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2025-05-28 16:45:26.402046 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2025-05-28 16:45:26.45804 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2025-05-28 16:45:26.526274 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2025-05-28 16:45:26.582618 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2025-05-28 16:45:26.639602 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2025-05-28 16:45:26.696091 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2025-05-28 16:45:26.762093 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2025-05-28 16:45:26.821702 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2025-05-28 16:45:26.879422 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2025-05-28 16:45:26.938189 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2025-05-28 16:45:26.997097 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2025-05-28 16:45:27.068667 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2025-05-28 16:45:27.125606 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2025-05-28 16:45:27.184939 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2025-05-28 16:45:27.24105 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2025-05-28 16:45:27.299103 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2025-05-28 16:45:27.367986 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2025-05-28 16:45:27.424501 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2025-05-28 16:45:27.483454 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2025-05-28 16:45:27.542098 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2025-05-28 16:45:27.632116 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2025-05-28 16:45:27.695856 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2025-05-28 16:45:27.756165 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2025-05-28 16:45:27.815731 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2025-05-28 16:45:27.873633 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2025-05-28 16:45:27.942895 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2025-05-28 16:45:28.001048 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2025-05-28 16:45:28.058358 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2025-05-28 16:45:28.11738 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2025-05-28 16:45:28.172724 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2025-05-28 16:45:28.242871 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2025-05-28 16:45:28.303414 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2025-05-28 16:45:28.361606 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2025-05-28 16:45:28.417915 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2025-05-28 16:45:28.475131 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2025-05-28 16:45:28.546965 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2025-05-28 16:45:28.607152 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2025-05-28 16:45:28.665382 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2025-05-28 16:45:28.722613 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2025-05-28 16:45:28.7825 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2025-05-28 16:45:28.856026 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2025-05-28 16:45:28.916369 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2025-05-28 16:45:28.974359 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2025-05-28 16:45:29.031317 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2025-05-28 16:45:29.089024 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2025-05-28 16:45:29.165903 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2025-05-28 16:45:29.231833 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2025-05-28 16:45:29.29027 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2025-05-28 16:45:29.349377 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2025-05-28 16:45:29.408493 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2025-05-28 16:45:29.481354 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2025-05-28 16:45:29.54221 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2025-05-28 16:45:29.600306 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2025-05-28 16:45:29.665906 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2025-05-28 16:45:29.731262 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2025-05-28 16:45:29.7959 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2025-05-28 16:45:29.853305 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2025-05-28 16:45:29.911461 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2025-05-28 16:45:29.968679 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2025-05-28 16:45:30.03898 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2025-05-28 16:45:30.09998 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2025-05-28 16:45:30.160644 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2025-05-28 16:45:30.2187 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2025-05-28 16:45:30.27622 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2025-05-28 16:45:30.348282 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2025-05-28 16:45:30.408905 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2025-05-28 16:45:30.467559 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2025-05-28 16:45:30.525058 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2025-05-28 16:45:30.580812 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2025-05-28 16:45:30.652077 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2025-05-28 16:45:30.710341 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2025-05-28 16:45:30.768569 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2025-05-28 16:45:30.825644 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2025-05-28 16:45:30.883384 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2025-05-28 16:45:30.955131 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2025-05-28 16:45:31.014405 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2025-05-28 16:45:31.074264 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2025-05-28 16:45:31.135428 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2025-05-28 16:45:31.213538 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2025-05-28 16:45:31.282047 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2025-05-28 16:45:31.342956 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2025-05-28 16:45:31.403395 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2025-05-28 16:45:31.464399 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2025-05-28 16:45:31.537153 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2025-05-28 16:45:31.597682 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2025-05-28 16:45:31.657392 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2025-05-28 16:45:31.715329 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2025-05-28 16:45:31.773743 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2025-05-28 16:45:31.848622 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2025-05-28 16:45:31.908703 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2025-05-28 16:45:31.97038 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2025-05-28 16:45:32.028968 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2025-05-28 16:45:32.088588 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2025-05-28 16:45:32.1645 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2025-05-28 16:45:32.224764 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2025-05-28 16:45:32.287975 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2025-05-28 16:45:32.347778 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2025-05-28 16:45:32.420557 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2025-05-28 16:45:32.480442 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2025-05-28 16:45:32.538895 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2025-05-28 16:45:32.598857 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2025-05-28 16:45:32.660956 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2025-05-28 16:45:32.733248 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2025-05-28 16:45:32.795584 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2025-05-28 16:45:32.856167 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2025-05-28 16:45:32.914725 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2025-05-28 16:45:32.972241 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2025-05-28 16:45:33.044794 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2025-05-28 16:45:33.103375 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2025-05-28 16:45:33.161235 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2025-05-28 16:45:33.218588 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2025-05-28 16:45:33.291299 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2025-05-28 16:45:33.35355 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2025-05-28 16:45:33.411108 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2025-05-28 16:45:33.467997 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2025-05-28 16:45:33.526898 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2025-05-28 16:45:33.601851 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2025-05-28 16:45:33.664506 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2025-05-28 16:45:33.726469 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2025-05-28 16:45:33.786267 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2025-05-28 16:45:34.227241 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2025-05-28 16:45:34.288594 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2025-05-28 16:45:34.346358 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2025-05-28 16:45:34.404851 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2025-05-28 16:45:34.469117 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2025-05-28 16:45:34.541471 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2025-05-28 16:45:34.602356 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2025-05-28 16:45:34.658656 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2025-05-28 16:45:34.715773 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2025-05-28 16:45:34.772578 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2025-05-28 16:45:34.834923 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2025-05-28 16:45:34.890822 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2025-05-28 16:45:34.946491 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2025-05-28 16:45:35.00457 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2025-05-28 16:45:35.064443 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2025-05-28 16:45:35.126736 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2025-05-28 16:45:35.183956 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2025-05-28 16:45:35.241047 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2025-05-28 16:45:35.298789 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2025-05-28 16:45:35.357352 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2025-05-28 16:45:35.426206 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2025-05-28 16:45:35.486262 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2025-05-28 16:45:35.542155 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2025-05-28 16:45:35.59811 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2025-05-28 16:45:35.65554 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2025-05-28 16:45:35.723179 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2025-05-28 16:45:35.784106 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2025-05-28 16:45:35.842042 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2025-05-28 16:45:35.899064 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2025-05-28 16:45:35.960377 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2025-05-28 16:45:36.023594 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2025-05-28 16:45:36.078839 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2025-05-28 16:45:36.139095 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2025-05-28 16:45:36.197086 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2025-05-28 16:45:36.254912 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2025-05-28 16:45:36.316401 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2025-05-28 16:45:36.373425 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2025-05-28 16:45:36.436725 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2025-05-28 16:45:36.497625 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2025-05-28 16:45:36.554558 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2025-05-28 16:45:36.619969 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2025-05-28 16:45:36.677794 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2025-05-28 16:45:36.738567 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2025-05-28 16:45:36.796363 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2025-05-28 16:45:36.859298 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2025-05-28 16:45:36.917032 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2025-05-28 16:45:36.973769 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2025-05-28 16:45:37.03283 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2025-05-28 16:45:37.09042 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2025-05-28 16:45:37.15103 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2025-05-28 16:45:37.206896 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2025-05-28 16:45:37.263058 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2025-05-28 16:45:37.320903 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2025-05-28 16:45:37.377883 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2025-05-28 16:45:37.439425 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2025-05-28 16:45:37.494682 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2025-05-28 16:45:37.549782 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2025-05-28 16:45:37.605829 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2025-05-28 16:45:37.662606 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2025-05-28 16:45:37.724033 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2025-05-28 16:45:37.780967 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2025-05-28 16:45:37.837636 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2025-05-28 16:45:37.894326 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2025-05-28 16:45:37.953256 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2025-05-28 16:45:38.016169 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2025-05-28 16:45:38.072823 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2025-05-28 16:45:38.128992 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2025-05-28 16:45:38.185045 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2025-05-28 16:45:38.247221 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2025-05-28 16:45:38.302783 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2025-05-28 16:45:38.359347 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2025-05-28 16:45:38.416272 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2025-05-28 16:45:38.473198 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2025-05-28 16:45:38.536424 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2025-05-28 16:45:38.593206 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2025-05-28 16:45:38.649807 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2025-05-28 16:45:38.706551 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2025-05-28 16:45:38.762806 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2025-05-28 16:45:38.824012 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2025-05-28 16:45:38.880308 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2025-05-28 16:45:38.936025 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2025-05-28 16:45:38.992143 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2025-05-28 16:45:39.048243 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2025-05-28 16:45:39.10882 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2025-05-28 16:45:39.164911 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2025-05-28 16:45:39.221084 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2025-05-28 16:45:39.278509 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2025-05-28 16:45:39.34216 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2025-05-28 16:45:39.398668 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2025-05-28 16:45:39.455099 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2025-05-28 16:45:39.512053 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2025-05-28 16:45:39.568696 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2025-05-28 16:45:39.630047 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2025-05-28 16:45:39.684029 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2025-05-28 16:45:39.738771 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2025-05-28 16:45:39.794669 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2025-05-28 16:45:39.851023 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2025-05-28 16:45:39.913133 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2025-05-28 16:45:39.968014 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2025-05-28 16:45:40.0314 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2025-05-28 16:45:40.093859 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2025-05-28 16:45:40.185685 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2025-05-28 16:45:40.247305 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2025-05-28 16:45:40.315351 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2025-05-28 16:45:40.376431 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2025-05-28 16:45:40.438941 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2025-05-28 16:45:40.514797 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2025-05-28 16:45:40.57333 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2025-05-28 16:45:40.631453 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2025-05-28 16:45:40.689232 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2025-05-28 16:45:40.746728 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2025-05-28 16:45:40.812954 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2025-05-28 16:45:40.869706 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2025-05-28 16:45:40.926618 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2025-05-28 16:45:40.984924 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2025-05-28 16:45:41.042115 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2025-05-28 16:45:41.112153 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2025-05-28 16:45:41.17117 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2025-05-28 16:45:41.228151 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2025-05-28 16:45:41.285862 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2025-05-28 16:45:41.345815 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2025-05-28 16:45:41.419426 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2025-05-28 16:45:41.483851 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2025-05-28 16:45:41.540494 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2025-05-28 16:45:41.598801 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2025-05-28 16:45:41.657301 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2025-05-28 16:45:41.729136 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2025-05-28 16:45:41.786734 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2025-05-28 16:45:41.842765 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2025-05-28 16:45:41.898618 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2025-05-28 16:45:41.95919 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2025-05-28 16:45:42.026204 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2025-05-28 16:45:42.082062 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2025-05-28 16:45:42.137994 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2025-05-28 16:45:42.195176 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2025-05-28 16:45:42.253094 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2025-05-28 16:45:42.327643 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2025-05-28 16:45:42.386121 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2025-05-28 16:45:42.449488 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2025-05-28 16:45:42.505806 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2025-05-28 16:45:42.574338 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2025-05-28 16:45:42.633546 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2025-05-28 16:45:42.690841 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2025-05-28 16:45:42.756592 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2025-05-28 16:45:42.816516 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2025-05-28 16:45:42.892364 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2025-05-28 16:45:42.95523 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2025-05-28 16:45:43.017851 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2025-05-28 16:45:43.082443 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2025-05-28 16:45:43.147341 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2025-05-28 16:45:43.227323 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2025-05-28 16:45:43.283945 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2025-05-28 16:45:43.341847 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2025-05-28 16:45:43.398193 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2025-05-28 16:45:43.454634 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2025-05-28 16:45:43.521523 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2025-05-28 16:45:43.576382 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2025-05-28 16:45:43.632248 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2025-05-28 16:45:43.69038 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2025-05-28 16:45:43.748395 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2025-05-28 16:45:43.817826 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2025-05-28 16:45:43.87894 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2025-05-28 16:45:43.934439 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2025-05-28 16:45:43.989736 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2025-05-28 16:45:44.056274 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2025-05-28 16:45:44.112473 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2025-05-28 16:45:44.167931 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2025-05-28 16:45:44.22567 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2025-05-28 16:45:44.283214 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2025-05-28 16:45:44.350048 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2025-05-28 16:45:44.405745 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2025-05-28 16:45:44.460898 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2025-05-28 16:45:44.516845 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2025-05-28 16:45:44.572374 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2025-05-28 16:45:44.63985 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2025-05-28 16:45:44.696122 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2025-05-28 16:45:44.7563 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2025-05-28 16:45:44.813536 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2025-05-28 16:45:44.876069 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2025-05-28 16:45:44.937105 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2025-05-28 16:45:44.992855 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2025-05-28 16:45:45.048615 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2025-05-28 16:45:45.104058 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2025-05-28 16:45:45.170584 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2025-05-28 16:45:45.22851 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2025-05-28 16:45:45.283248 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2025-05-28 16:45:45.339407 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2025-05-28 16:45:45.396911 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2025-05-28 16:45:45.468513 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2025-05-28 16:45:45.526673 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2025-05-28 16:45:45.586384 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2025-05-28 16:45:45.642503 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2025-05-28 16:45:45.698915 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2025-05-28 16:45:45.765195 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2025-05-28 16:45:45.823937 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2025-05-28 16:45:45.879728 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2025-05-28 16:45:45.942621 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2025-05-28 16:45:46.011675 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2025-05-28 16:45:46.072005 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2025-05-28 16:45:46.130937 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2025-05-28 16:45:46.188311 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2025-05-28 16:45:46.247434 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2025-05-28 16:45:46.364329 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2025-05-28 16:45:46.427886 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2025-05-28 16:45:46.484278 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2025-05-28 16:45:46.546678 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2025-05-28 16:45:46.615293 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2025-05-28 16:45:46.68687 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2025-05-28 16:45:46.744516 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2025-05-28 16:45:46.801159 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2025-05-28 16:45:46.857803 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2025-05-28 16:45:46.915821 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2025-05-28 16:45:46.980362 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2025-05-28 16:45:47.038476 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2025-05-28 16:45:47.0968 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2025-05-28 16:45:47.155385 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2025-05-28 16:45:47.212562 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2025-05-28 16:45:47.277585 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2025-05-28 16:45:47.335817 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2025-05-28 16:45:47.396881 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2025-05-28 16:45:47.452907 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2025-05-28 16:45:47.519714 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2025-05-28 16:45:47.582428 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2025-05-28 16:45:47.641874 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2025-05-28 16:45:47.701746 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2025-05-28 16:45:47.761287 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2025-05-28 16:45:47.828626 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2025-05-28 16:45:47.887651 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2025-05-28 16:45:47.946234 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2025-05-28 16:45:48.005141 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2025-05-28 16:45:48.064741 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2025-05-28 16:45:48.13159 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2025-05-28 16:45:48.190354 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2025-05-28 16:45:48.247993 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2025-05-28 16:45:48.95779 INFO::Plotting data for metadata number 2, antibiotics
## 2025-05-28 16:45:48.95864 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2025-05-28 16:45:49.018365 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2025-05-28 16:45:49.078636 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2025-05-28 16:45:49.14747 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2025-05-28 16:45:49.207279 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2025-05-28 16:45:49.26832 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2025-05-28 16:45:49.330012 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2025-05-28 16:45:49.400647 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2025-05-28 16:45:49.467793 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2025-05-28 16:45:49.528926 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2025-05-28 16:45:49.590036 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2025-05-28 16:45:49.656682 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2025-05-28 16:45:49.73314 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2025-05-28 16:45:49.808428 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2025-05-28 16:45:49.877063 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2025-05-28 16:45:49.94725 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2025-05-28 16:45:50.021648 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2025-05-28 16:45:50.092404 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2025-05-28 16:45:50.156777 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2025-05-28 16:45:50.218229 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2025-05-28 16:45:50.286734 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2025-05-28 16:45:50.361558 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2025-05-28 16:45:50.426429 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2025-05-28 16:45:50.489515 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2025-05-28 16:45:50.553557 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2025-05-28 16:45:50.623225 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2025-05-28 16:45:50.685372 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2025-05-28 16:45:50.746215 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2025-05-28 16:45:50.806984 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2025-05-28 16:45:50.877577 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2025-05-28 16:45:50.943828 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2025-05-28 16:45:51.00641 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2025-05-28 16:45:51.068549 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2025-05-28 16:45:51.131625 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2025-05-28 16:45:51.210259 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2025-05-28 16:45:51.273743 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2025-05-28 16:45:51.335693 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2025-05-28 16:45:51.39811 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2025-05-28 16:45:51.470418 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2025-05-28 16:45:51.534278 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2025-05-28 16:45:51.595932 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2025-05-28 16:45:51.656733 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2025-05-28 16:45:51.719243 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2025-05-28 16:45:51.792706 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2025-05-28 16:45:51.854944 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2025-05-28 16:45:51.917871 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2025-05-28 16:45:51.982087 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2025-05-28 16:45:52.051196 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2025-05-28 16:45:52.113523 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2025-05-28 16:45:52.175379 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2025-05-28 16:45:52.236539 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2025-05-28 16:45:52.307695 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2025-05-28 16:45:52.369156 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2025-05-28 16:45:52.429159 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2025-05-28 16:45:52.491385 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2025-05-28 16:45:52.553245 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2025-05-28 16:45:52.657278 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2025-05-28 16:45:52.723619 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2025-05-28 16:45:52.786152 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2025-05-28 16:45:52.848504 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2025-05-28 16:45:52.924749 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2025-05-28 16:45:52.988276 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2025-05-28 16:45:53.050436 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2025-05-28 16:45:53.111637 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2025-05-28 16:45:53.171885 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2025-05-28 16:45:53.246417 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2025-05-28 16:45:53.311987 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2025-05-28 16:45:53.374134 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2025-05-28 16:45:53.436714 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2025-05-28 16:45:53.513751 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2025-05-28 16:45:53.576781 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2025-05-28 16:45:53.639673 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2025-05-28 16:45:53.70079 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2025-05-28 16:45:53.761106 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2025-05-28 16:45:53.837644 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2025-05-28 16:45:53.900523 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2025-05-28 16:45:53.962617 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2025-05-28 16:45:54.025828 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2025-05-28 16:45:54.108816 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2025-05-28 16:45:54.169942 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2025-05-28 16:45:54.236255 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2025-05-28 16:45:54.298587 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2025-05-28 16:45:54.360923 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2025-05-28 16:45:54.435863 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2025-05-28 16:45:54.500382 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2025-05-28 16:45:54.562868 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2025-05-28 16:45:54.623817 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2025-05-28 16:45:54.697363 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2025-05-28 16:45:54.76029 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2025-05-28 16:45:54.821683 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2025-05-28 16:45:54.882529 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2025-05-28 16:45:54.943831 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2025-05-28 16:45:55.020878 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2025-05-28 16:45:55.095743 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2025-05-28 16:45:55.158363 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2025-05-28 16:45:55.219543 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2025-05-28 16:45:55.294337 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2025-05-28 16:45:55.355527 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2025-05-28 16:45:55.422476 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2025-05-28 16:45:55.485926 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2025-05-28 16:45:55.549335 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2025-05-28 16:45:55.6278 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2025-05-28 16:45:55.690828 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2025-05-28 16:45:55.752582 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2025-05-28 16:45:55.81293 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2025-05-28 16:45:55.888373 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2025-05-28 16:45:55.950301 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2025-05-28 16:45:56.012801 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2025-05-28 16:45:56.073505 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2025-05-28 16:45:56.147516 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2025-05-28 16:45:56.21609 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2025-05-28 16:45:56.276763 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2025-05-28 16:45:56.336944 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2025-05-28 16:45:56.39784 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2025-05-28 16:45:56.473046 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2025-05-28 16:45:56.535768 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2025-05-28 16:45:56.597665 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2025-05-28 16:45:56.66066 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2025-05-28 16:45:56.738679 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2025-05-28 16:45:56.808114 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2025-05-28 16:45:56.871831 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2025-05-28 16:45:56.931308 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2025-05-28 16:45:56.99418 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2025-05-28 16:45:57.072135 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2025-05-28 16:45:57.135988 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2025-05-28 16:45:57.200372 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2025-05-28 16:45:57.260925 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2025-05-28 16:45:57.336156 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2025-05-28 16:45:57.399746 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2025-05-28 16:45:57.461988 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2025-05-28 16:45:57.523701 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2025-05-28 16:45:57.600185 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2025-05-28 16:45:57.664126 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2025-05-28 16:45:57.73381 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2025-05-28 16:45:57.796247 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2025-05-28 16:45:57.858761 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2025-05-28 16:45:57.936285 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2025-05-28 16:45:58.001692 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2025-05-28 16:45:58.065106 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2025-05-28 16:45:58.126864 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2025-05-28 16:45:58.206311 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2025-05-28 16:45:58.271848 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2025-05-28 16:45:58.333786 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2025-05-28 16:45:58.396785 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2025-05-28 16:45:58.481714 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2025-05-28 16:45:58.544456 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2025-05-28 16:45:58.60708 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2025-05-28 16:45:58.667827 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2025-05-28 16:45:58.729124 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2025-05-28 16:45:58.860591 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2025-05-28 16:45:58.92627 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2025-05-28 16:45:59.000768 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2025-05-28 16:45:59.072274 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2025-05-28 16:45:59.154676 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2025-05-28 16:45:59.224518 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2025-05-28 16:45:59.293545 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2025-05-28 16:45:59.357867 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2025-05-28 16:45:59.42472 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2025-05-28 16:45:59.514965 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2025-05-28 16:45:59.585915 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2025-05-28 16:45:59.652461 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2025-05-28 16:45:59.718679 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2025-05-28 16:45:59.804656 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2025-05-28 16:45:59.879212 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2025-05-28 16:45:59.95484 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2025-05-28 16:46:00.019629 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2025-05-28 16:46:00.082522 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2025-05-28 16:46:00.156882 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2025-05-28 16:46:00.218509 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2025-05-28 16:46:00.281357 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2025-05-28 16:46:00.341737 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2025-05-28 16:46:00.413019 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2025-05-28 16:46:00.476314 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2025-05-28 16:46:00.539381 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2025-05-28 16:46:00.599962 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2025-05-28 16:46:00.660357 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2025-05-28 16:46:00.733118 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2025-05-28 16:46:00.795855 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2025-05-28 16:46:00.861841 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2025-05-28 16:46:00.924778 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2025-05-28 16:46:01.002345 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2025-05-28 16:46:01.064068 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2025-05-28 16:46:01.130121 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2025-05-28 16:46:01.191192 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2025-05-28 16:46:01.250514 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2025-05-28 16:46:01.321681 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2025-05-28 16:46:01.384208 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2025-05-28 16:46:01.446068 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2025-05-28 16:46:01.506468 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2025-05-28 16:46:01.582633 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2025-05-28 16:46:01.651537 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2025-05-28 16:46:01.727066 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2025-05-28 16:46:01.788232 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2025-05-28 16:46:01.858392 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2025-05-28 16:46:01.925469 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2025-05-28 16:46:01.991411 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2025-05-28 16:46:02.059041 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2025-05-28 16:46:02.123661 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2025-05-28 16:46:02.200177 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2025-05-28 16:46:02.273867 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2025-05-28 16:46:02.339108 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2025-05-28 16:46:02.404938 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2025-05-28 16:46:02.486912 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2025-05-28 16:46:02.557068 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2025-05-28 16:46:02.62782 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2025-05-28 16:46:02.69691 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2025-05-28 16:46:02.759454 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2025-05-28 16:46:02.837906 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2025-05-28 16:46:02.90361 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2025-05-28 16:46:02.96923 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2025-05-28 16:46:03.030673 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2025-05-28 16:46:03.106856 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2025-05-28 16:46:03.174592 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2025-05-28 16:46:03.23674 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2025-05-28 16:46:03.302304 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2025-05-28 16:46:03.374598 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2025-05-28 16:46:03.438285 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2025-05-28 16:46:03.499842 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2025-05-28 16:46:03.560494 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2025-05-28 16:46:03.621202 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2025-05-28 16:46:03.699216 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2025-05-28 16:46:03.761783 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2025-05-28 16:46:03.824903 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2025-05-28 16:46:03.885856 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2025-05-28 16:46:03.958887 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2025-05-28 16:46:04.0224 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2025-05-28 16:46:04.085944 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2025-05-28 16:46:04.148346 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2025-05-28 16:46:04.209669 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2025-05-28 16:46:04.28499 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2025-05-28 16:46:04.349441 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2025-05-28 16:46:04.414314 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2025-05-28 16:46:04.475894 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2025-05-28 16:46:04.54888 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2025-05-28 16:46:04.611961 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2025-05-28 16:46:04.676994 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2025-05-28 16:46:04.73851 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2025-05-28 16:46:04.812519 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2025-05-28 16:46:04.877318 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2025-05-28 16:46:04.940738 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2025-05-28 16:46:05.002936 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2025-05-28 16:46:05.063714 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2025-05-28 16:46:05.164869 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2025-05-28 16:46:05.22754 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2025-05-28 16:46:05.28995 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2025-05-28 16:46:05.352079 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2025-05-28 16:46:05.429537 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2025-05-28 16:46:05.493681 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2025-05-28 16:46:05.559324 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2025-05-28 16:46:05.626375 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2025-05-28 16:46:05.687795 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2025-05-28 16:46:05.767961 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2025-05-28 16:46:05.835383 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2025-05-28 16:46:05.902384 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2025-05-28 16:46:05.969202 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2025-05-28 16:46:06.047439 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2025-05-28 16:46:06.112361 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2025-05-28 16:46:06.176051 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2025-05-28 16:46:06.238267 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2025-05-28 16:46:06.299832 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2025-05-28 16:46:06.382941 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2025-05-28 16:46:06.448111 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2025-05-28 16:46:06.516674 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2025-05-28 16:46:06.580565 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2025-05-28 16:46:06.658941 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2025-05-28 16:46:06.723899 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2025-05-28 16:46:06.793048 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2025-05-28 16:46:06.85828 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2025-05-28 16:46:06.921208 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2025-05-28 16:46:07.008266 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2025-05-28 16:46:07.074921 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2025-05-28 16:46:07.137008 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2025-05-28 16:46:07.198665 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2025-05-28 16:46:07.279081 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2025-05-28 16:46:07.344793 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2025-05-28 16:46:07.41018 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2025-05-28 16:46:07.475919 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2025-05-28 16:46:07.538928 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2025-05-28 16:46:07.621107 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2025-05-28 16:46:07.689355 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2025-05-28 16:46:07.754362 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2025-05-28 16:46:07.816789 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2025-05-28 16:46:07.896127 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2025-05-28 16:46:07.964474 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2025-05-28 16:46:08.034609 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2025-05-28 16:46:08.101104 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2025-05-28 16:46:08.172794 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2025-05-28 16:46:08.246578 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2025-05-28 16:46:08.312806 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2025-05-28 16:46:08.375233 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2025-05-28 16:46:08.438409 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2025-05-28 16:46:08.518248 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2025-05-28 16:46:08.583134 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2025-05-28 16:46:08.648334 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2025-05-28 16:46:08.710612 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2025-05-28 16:46:08.795044 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2025-05-28 16:46:08.860696 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2025-05-28 16:46:08.92444 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2025-05-28 16:46:08.991419 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2025-05-28 16:46:09.054802 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2025-05-28 16:46:09.135749 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2025-05-28 16:46:09.198068 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2025-05-28 16:46:09.263562 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2025-05-28 16:46:09.32584 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2025-05-28 16:46:09.408328 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2025-05-28 16:46:09.477782 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2025-05-28 16:46:09.54738 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2025-05-28 16:46:09.61151 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2025-05-28 16:46:09.685655 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2025-05-28 16:46:09.757393 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2025-05-28 16:46:09.822263 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2025-05-28 16:46:09.885868 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2025-05-28 16:46:09.947524 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2025-05-28 16:46:10.029065 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2025-05-28 16:46:10.096578 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2025-05-28 16:46:10.159825 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2025-05-28 16:46:10.221428 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2025-05-28 16:46:10.318168 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2025-05-28 16:46:10.404117 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2025-05-28 16:46:10.468568 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2025-05-28 16:46:10.530253 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2025-05-28 16:46:10.600111 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2025-05-28 16:46:10.672414 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2025-05-28 16:46:10.736416 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2025-05-28 16:46:10.809499 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2025-05-28 16:46:10.883999 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2025-05-28 16:46:10.970379 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2025-05-28 16:46:11.048784 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2025-05-28 16:46:11.128113 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2025-05-28 16:46:11.194233 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2025-05-28 16:46:11.302435 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2025-05-28 16:46:11.376416 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2025-05-28 16:46:11.453029 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2025-05-28 16:46:11.523272 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2025-05-28 16:46:12.004952 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2025-05-28 16:46:12.066333 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2025-05-28 16:46:12.127044 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2025-05-28 16:46:12.19844 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2025-05-28 16:46:12.282543 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2025-05-28 16:46:12.359753 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2025-05-28 16:46:12.422801 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2025-05-28 16:46:12.495185 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2025-05-28 16:46:12.560351 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2025-05-28 16:46:12.623777 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2025-05-28 16:46:12.706993 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2025-05-28 16:46:12.766705 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2025-05-28 16:46:12.827764 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2025-05-28 16:46:12.888824 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2025-05-28 16:46:12.954536 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2025-05-28 16:46:13.01499 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2025-05-28 16:46:13.081036 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2025-05-28 16:46:13.142236 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2025-05-28 16:46:13.212261 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2025-05-28 16:46:13.27636 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2025-05-28 16:46:13.335771 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2025-05-28 16:46:13.39535 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2025-05-28 16:46:13.457798 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2025-05-28 16:46:13.527723 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2025-05-28 16:46:13.589275 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2025-05-28 16:46:13.64887 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2025-05-28 16:46:13.707771 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2025-05-28 16:46:13.767591 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2025-05-28 16:46:13.831064 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2025-05-28 16:46:13.889042 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2025-05-28 16:46:13.946986 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2025-05-28 16:46:14.007238 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2025-05-28 16:46:14.07266 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2025-05-28 16:46:14.132162 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2025-05-28 16:46:14.191234 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2025-05-28 16:46:14.249628 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2025-05-28 16:46:14.309778 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2025-05-28 16:46:14.374097 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2025-05-28 16:46:14.432964 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2025-05-28 16:46:14.492034 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2025-05-28 16:46:14.550437 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2025-05-28 16:46:14.609612 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2025-05-28 16:46:14.67162 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2025-05-28 16:46:14.730562 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2025-05-28 16:46:14.790309 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2025-05-28 16:46:14.8514 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2025-05-28 16:46:14.920852 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2025-05-28 16:46:14.981137 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2025-05-28 16:46:15.040508 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2025-05-28 16:46:15.099738 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2025-05-28 16:46:15.163346 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2025-05-28 16:46:15.230824 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2025-05-28 16:46:15.290494 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2025-05-28 16:46:15.352245 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2025-05-28 16:46:15.41329 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2025-05-28 16:46:15.480473 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2025-05-28 16:46:15.539443 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2025-05-28 16:46:15.597943 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2025-05-28 16:46:15.663238 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2025-05-28 16:46:15.728394 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2025-05-28 16:46:15.797018 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2025-05-28 16:46:15.86034 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2025-05-28 16:46:15.922758 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2025-05-28 16:46:15.982159 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2025-05-28 16:46:16.047799 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2025-05-28 16:46:16.110199 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2025-05-28 16:46:16.170502 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2025-05-28 16:46:16.231939 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2025-05-28 16:46:16.297831 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2025-05-28 16:46:16.36251 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2025-05-28 16:46:16.424488 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2025-05-28 16:46:16.491244 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2025-05-28 16:46:16.562075 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2025-05-28 16:46:16.634593 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2025-05-28 16:46:16.696934 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2025-05-28 16:46:16.760022 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2025-05-28 16:46:16.826098 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2025-05-28 16:46:16.897135 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2025-05-28 16:46:16.966056 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2025-05-28 16:46:17.043471 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2025-05-28 16:46:17.105601 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2025-05-28 16:46:17.166582 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2025-05-28 16:46:17.233206 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2025-05-28 16:46:17.295043 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2025-05-28 16:46:17.356582 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2025-05-28 16:46:17.420708 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2025-05-28 16:46:17.49164 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2025-05-28 16:46:17.554647 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2025-05-28 16:46:17.616264 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2025-05-28 16:46:17.674968 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2025-05-28 16:46:17.734248 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2025-05-28 16:46:17.797182 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2025-05-28 16:46:17.859046 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2025-05-28 16:46:17.921112 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2025-05-28 16:46:17.982172 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2025-05-28 16:46:18.075833 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2025-05-28 16:46:18.136036 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2025-05-28 16:46:18.195537 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2025-05-28 16:46:18.255341 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2025-05-28 16:46:18.315643 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2025-05-28 16:46:18.38678 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2025-05-28 16:46:18.44704 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2025-05-28 16:46:18.510435 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2025-05-28 16:46:19.262114 INFO::Plotting data for metadata number 3, age
## 2025-05-28 16:46:19.262925 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:19.385678 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:19.477693 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:19.548904 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:19.610953 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:19.685873 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:19.749558 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:19.809678 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:19.874831 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:19.950071 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:20.012343 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.079268 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.147831 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.232748 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.308887 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.378174 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.44484 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.520711 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.602125 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.670024 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:20.733512 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:20.81377 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:20.88117 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:20.940123 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.005502 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.07691 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.141393 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.207238 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.275419 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.344827 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.408459 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.474162 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.540204 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.601307 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.681997 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.746784 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.809632 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:21.882678 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:21.953836 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:22.014869 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.078956 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.147385 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.222411 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.28727 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.354509 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.430231 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.507149 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:22.566678 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:22.626663 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.691199 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:22.764567 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.83286 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.896362 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:22.9603 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.031913 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.096718 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.160718 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.231147 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.299384 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.357651 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.416294 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.480112 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.548643 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.606896 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.669879 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.72937 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.805412 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:23.872271 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.93264 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:23.992986 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.109041 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:24.172286 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.241618 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.313009 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.388114 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:24.449249 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.514344 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.57874 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.656115 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.723994 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:24.789023 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.853271 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:24.933134 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.007555 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.073402 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.133604 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.203986 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.270173 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.330109 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.391934 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.462253 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.528559 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.59523 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.659642 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:25.733221 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.794147 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.85467 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.914673 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:25.976695 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.048371 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.109993 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.1748 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.240727 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.312409 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.379165 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.438685 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.498422 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.570528 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.634633 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:26.699141 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.760506 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.834695 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.896632 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:26.956943 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.01803 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.089807 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.157292 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.218172 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.283332 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.357153 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.422581 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.482698 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.547047 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.621351 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.689462 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.754015 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.814585 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:27.884409 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:27.949443 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.015892 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.082694 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:28.155656 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.221732 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.286866 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.353037 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.429147 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:28.500314 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.567316 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:28.628428 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:28.700431 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.774824 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.840779 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:28.905657 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:28.975053 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.041963 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.119932 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:29.180218 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:29.250634 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.315226 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:29.374975 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.439504 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.513253 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.581324 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:29.643203 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.71091 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.812271 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:29.874921 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:29.939707 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:30.002829 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:30.078656 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:30.146538 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2025-05-28 16:46:30.207824 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:30.271975 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-05-28 16:46:30.352594 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2025-05-28 16:46:31.132693 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2025-05-28 16:46:31.137866 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2025-05-28 16:46:31.147032 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R version 4.5.0 Patched (2025-04-21 r88169)
## Platform: aarch64-apple-darwin20
## Running under: macOS Ventura 13.7.1
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; LAPACK version 3.12.1
##
## locale:
## [1] C/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.13.0 SummarizedExperiment_1.39.0
## [3] Biobase_2.69.0 GenomicRanges_1.61.0
## [5] GenomeInfoDb_1.45.4 IRanges_2.43.0
## [7] S4Vectors_0.47.0 BiocGenerics_0.55.0
## [9] generics_0.1.4 MatrixGenerics_1.21.0
## [11] matrixStats_1.5.0 BiocStyle_2.37.0
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.6 magrittr_2.0.3
## [7] compiler_4.5.0 RSQLite_2.3.11 mgcv_1.9-3
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.49.0 labeling_0.4.3
## [19] rmarkdown_2.29 UCSC.utils_1.5.0 preprocessCore_1.71.0
## [22] bit_4.6.0 xfun_0.52 cachem_1.1.0
## [25] jsonlite_2.0.0 blob_1.2.4 DelayedArray_0.35.1
## [28] BiocParallel_1.43.2 psych_2.5.3 parallel_4.5.0
## [31] Maaslin2_1.23.0 cluster_2.1.8.1 biglm_0.9-3
## [34] R6_2.6.1 bslib_0.9.0 stringi_1.8.7
## [37] RColorBrewer_1.1-3 rpart_4.1.24 jquerylib_0.1.4
## [40] Rcpp_1.0.14 bookdown_0.43 iterators_1.0.14
## [43] knitr_1.50 WGCNA_1.73 base64enc_0.1-3
## [46] Matrix_1.7-3 splines_4.5.0 nnet_7.3-20
## [49] tidyselect_1.2.1 rstudioapi_0.17.1 dichromat_2.0-0.1
## [52] abind_1.4-8 yaml_2.3.10 doParallel_1.0.17
## [55] codetools_0.2-20 plyr_1.8.9 lattice_0.22-7
## [58] tibble_3.2.1 withr_3.0.2 KEGGREST_1.49.0
## [61] evaluate_1.0.3 foreign_0.8-90 survival_3.8-3
## [64] getopt_1.20.4 Biostrings_2.77.1 pillar_1.10.2
## [67] BiocManager_1.30.25 checkmate_2.3.2 foreach_1.5.2
## [70] pcaPP_2.0-5 ggplot2_3.5.2 scales_1.4.0
## [73] glue_1.8.0 Hmisc_5.2-3 tools_4.5.0
## [76] robustbase_0.99-4-1 data.table_1.17.4 mvtnorm_1.3-3
## [79] fastcluster_1.3.0 grid_4.5.0 optparse_1.7.5
## [82] impute_1.83.0 AnnotationDbi_1.71.0 colorspace_2.1-1
## [85] nlme_3.1-168 htmlTable_2.4.3 Formula_1.2-5
## [88] cli_3.6.5 S4Arrays_1.9.1 dplyr_1.1.4
## [91] DEoptimR_1.1-3-1 gtable_0.3.6 hash_2.2.6.3
## [94] logging_0.10-108 dynamicTreeCut_1.63-1 sass_0.4.10
## [97] digest_0.6.37 SparseArray_1.9.0 htmlwidgets_1.6.4
## [100] farver_2.1.2 memoise_2.0.1 htmltools_0.5.8.1
## [103] lifecycle_1.0.4 httr_1.4.7 GO.db_3.21.0
## [106] bit64_4.6.0-1
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.