Package: G4SNVHunter
Type: Package
Title: Evaluating SNV-Induced Disruption of G-Quadruplex Structures
Version: 1.1.0
Authors@R: person("Rongxin", "Zhang", email = "rongxinzhang@outlook.com", 
           role = c("cre", "aut"),
           comment = c('ORCID' = "0000-0002-1643-1185"))
Description: 
    G-quadruplexes (G4s) are unique nucleic acid secondary structures 
    predominantly found in guanine-rich regions and have been shown to be 
    involved in various biological regulatory processes. G4SNVHunter is an R 
    package designed to rapidly identify genomic sequences with G4-forming 
    potential and accurately screen user-provided single nucleotide variants 
    (also applicable to single nucleotide polymorphisms) that may destabilize 
    these structures. This enables users to screen key variants for further 
    experimental study, investigating how these variants may influence 
    biological functions, such as gene regulation, by altering G4 formation.
Encoding: UTF-8
LazyData: false
Depends: R (>= 4.3.0)
Imports: Biostrings, stats, GenomicRanges, IRanges, Rcpp, RcppRoll,
        data.table, GenomeInfoDb, S4Vectors, ggplot2, cowplot,
        progress, ggseqlogo, viridis, ggpointdensity
LinkingTo: Rcpp
RoxygenNote: 7.3.2
License: MIT + file LICENSE
Suggests: knitr, BiocStyle, rmarkdown, BiocManager,
        BSgenome.Hsapiens.UCSC.hg19, DT, rtracklayer, testthat (>=
        3.0.0), RBGL
VignetteBuilder: knitr
biocViews: Epigenetics, SNP
News: NEWS.md
URL: https://github.com/rongxinzh/G4SNVHunter
BugReports: https://github.com/rongxinzh/G4SNVHunter/issues
Config/testthat/edition: 3
git_url: https://git.bioconductor.org/packages/G4SNVHunter
git_branch: devel
git_last_commit: 57ca828
git_last_commit_date: 2025-04-15
Repository: Bioconductor 3.22
Date/Publication: 2025-04-27
NeedsCompilation: yes
Packaged: 2025-04-27 20:21:07 UTC; biocbuild
Author: Rongxin Zhang [cre, aut] (ORCID:
    <https://orcid.org/0000-0002-1643-1185>)
Maintainer: Rongxin Zhang <rongxinzhang@outlook.com>
Built: R 4.5.0; aarch64-apple-darwin20; 2025-04-28 02:15:56 UTC; unix
